BACKGROUND: Endometrial adenocarcinoma is commonly seen in postmenopausal women and uterine bleeding is the first sign in 90% of the cases. Bone metastasis as the presenting feature is extremely rare. We report two endometrial cancer patients with metastasis to the tibia and cervical vertebra at the time of primary disease. CASES: Two patients were diagnosed with stage IVB endometrial cancer with involvement of the tibia and cervical column, respectively. The first case was treated with 8 cycles of platinum, doxorubicin, and cyclophosphamide, but she died 3 months after the completion of chemotherapy as a result of progressive disease. The second case received surgery followed by chemotherapy with cisplatin and doxorubicin, but she died 2 months later. CONCLUSIONS: These cases highlight the rare and unusual presentation of endometrial cancer. For this reason a review of the literature is also provided for all cases with evidence of bone metastasis at presentation of the disease, and as a recurrence. Copyright 2006 S. Karger AG, Basel.
BACKGROUND:Endometrial adenocarcinoma is commonly seen in postmenopausal women and uterine bleeding is the first sign in 90% of the cases. Bone metastasis as the presenting feature is extremely rare. We report two endometrial cancerpatients with metastasis to the tibia and cervical vertebra at the time of primary disease. CASES: Two patients were diagnosed with stage IVB endometrial cancer with involvement of the tibia and cervical column, respectively. The first case was treated with 8 cycles of platinum, doxorubicin, and cyclophosphamide, but she died 3 months after the completion of chemotherapy as a result of progressive disease. The second case received surgery followed by chemotherapy with cisplatin and doxorubicin, but she died 2 months later. CONCLUSIONS: These cases highlight the rare and unusual presentation of endometrial cancer. For this reason a review of the literature is also provided for all cases with evidence of bone metastasis at presentation of the disease, and as a recurrence. Copyright 2006 S. Karger AG, Basel.
Authors: Stefano Uccella; Jonathan M Morris; Jamie N Bakkum-Gamez; Gary L Keeney; Karl C Podratz; Andrea Mariani Journal: Gynecol Oncol Date: 2013-05-15 Impact factor: 5.482
Authors: Leszek Gottwald; Andrzej Dukowicz; Janusz Piekarski; Grazyna Pasz-Walczak; Michal Spych; Sylwia Kazmierczak-Lukaszewicz; Aleksandra Cialkowska-Rysz Journal: Arch Med Sci Date: 2012-02-29 Impact factor: 3.318
Authors: Pierre Lunardi; Fabien Vidal; Franck Accadbled; Pierre Leguevaque; Marc Soule-Tholy; Jean Baptiste Beauval; Stéphanie Motton Journal: Clin Case Rep Date: 2015-05-25