Literature DB >> 16191251

White-matter changes on MRI as surrogate marker.

Philip Scheltens1, Frederik Barkhof, Franz Fazekas.   

Abstract

This article reviews the use of white-matter changes as identified on MRI as a surrogate marker in clinical trials on vascular dementia. As of yet, insufficient evidence is present to implement rating or volumetric assessment of the burden of white-matter changes as surrogate marker in such trials, in view of the limited sensitivity to change of current methods and the high measurement error.

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Year:  2003        PMID： 16191251     DOI： 10.1017/S104161020300930X

Source DB:  PubMed          Journal:  Int Psychogeriatr        ISSN： 1041-6102            Impact factor:   3.878


  3 in total

1.  Superior cerebellar peduncle atrophy in Friedreich's ataxia correlates with disease symptoms.

Authors:  Hamed Akhlaghi; Louise Corben; Nellie Georgiou-Karistianis; John Bradshaw; Elsdon Storey; Martin B Delatycki; Gary F Egan
Journal:  Cerebellum       Date:  2011-03       Impact factor: 3.847

2.  Design, data management, and population baseline characteristics of the PERFORM magnetic resonance imaging project.

Authors:  P Maeder; L Bracoud; H Chabriat; A Gass; P Michel; M Hennerici
Journal:  J Neurol       Date:  2010-12-03       Impact factor: 4.849

3.  Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes.

Authors:  Masafumi Ihara; Hidekazu Tomimoto
Journal:  J Aging Res       Date:  2011-11-09
  3 in total

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