Literature DB >> 16190316

Failure of vitamin E in clinical trials: is gamma-tocopherol the answer?

Sridevi Devaraj1, Ishwarlal Jialal.   

Abstract

Oxidative stress and inflammation play a crucial role in atherosclerosis. However, prospective clinical trials of dietary antioxidants with anti-inflammatory properties, such as alpha-tocopherol (AT), have not yielded positive results. AT supplementation decreases gamma-tocopherol (GT) levels. GT is an antioxidant with potent anti-inflammatory activity, and plasma GT levels are inversely associated with cardiovascular diseases. Thus, studies using pure GT, alone or in conjunction with AT, will elucidate its utility in cardiovascular disease prevention.

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Year:  2005        PMID： 16190316     DOI： 10.1111/j.1753-4887.2005.tb00143.x

Source DB:  PubMed          Journal:  Nutr Rev        ISSN： 0029-6643            Impact factor:   7.110


  17 in total

1.  Tocopherol isoforms (α-, γ-, and δ-) show distinct capacities to control Nrf-2 and NfκB signaling pathways that modulate inflammatory response in Caco-2 intestinal cells.

Authors:  Ingrid Elisia; David D Kitts
Journal:  Mol Cell Biochem       Date:  2015-02-28       Impact factor: 3.396

Review 2.  Coronary heart disease prevention: nutrients, foods, and dietary patterns.

Authors:  Shilpa N Bhupathiraju; Katherine L Tucker
Journal:  Clin Chim Acta       Date:  2011-05-07       Impact factor: 3.786

Review 3.  Vitamin E in renal therapeutic regiments.

Authors:  Mohamed Alaa Thabet; James C M Chan
Journal:  Pediatr Nephrol       Date:  2006-09-21       Impact factor: 3.714

4.  Effects of vitamin E from supplements and diet on colonic α- and γ-tocopherol concentrations in persons at increased colon cancer risk.

Authors:  Yiting Li; Ananda Sen; Jianwei Ren; Leah M Askew; Elkhansa Sidahmed; Dean E Brenner; Mack T Ruffin; D Kim Turgeon; Zora Djuric
Journal:  Nutr Cancer       Date:  2014-11-05       Impact factor: 2.900

5.  Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease.

Authors:  Sridevi Devaraj; Rong Tang; Beverley Adams-Huet; Andrea Harris; Thanalakshmi Seenivasan; James A de Lemos; Ishwarlal Jialal
Journal:  Am J Clin Nutr       Date:  2007-11       Impact factor: 7.045

6.  Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.

Authors:  S Suri; X H Liu; S Rayment; D A Hughes; P A Kroon; P W Needs; M A Taylor; S Tribolo; V G Wilson
Journal:  Br J Pharmacol       Date:  2009-12-24       Impact factor: 8.739

7.  A validated liquid chromatography method for the simultaneous determination of vitamins A and E in human plasma.

Authors:  Danuta Siluk; Regina V Oliveira; Maria Esther-Rodriguez-Rosas; Shari Ling; Angelo Bos; Luigi Ferrucci; Irving W Wainer
Journal:  J Pharm Biomed Anal       Date:  2007-04-04       Impact factor: 3.935

8.  Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome.

Authors:  Sridevi Devaraj; Scott Leonard; Maret G Traber; Ishwarlal Jialal
Journal:  Free Radic Biol Med       Date:  2007-12-23       Impact factor: 7.376

9.  A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study.

Authors:  Nancy R Cook; Christine M Albert; J Michael Gaziano; Elaine Zaharris; Jean MacFadyen; Eleanor Danielson; Julie E Buring; JoAnn E Manson
Journal:  Arch Intern Med       Date:  2007 Aug 13-27

10.  Inhibition of oxidative metabolism of tocopherols with omega-N-heterocyclic derivatives of vitamin E.

Authors:  Stephan Ohnmacht; Phillip Nava; Ryan West; Robert Parker; Jeffrey Atkinson
Journal:  Bioorg Med Chem       Date:  2008-07-13       Impact factor: 3.641
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