Literature DB >> 16189666

Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing.

Judith Reinders1, Erik H Rozemuller, Rogier van Gent, Yvonne H A Arts-Hilkes, Jan G van den Tweel, Marcel G J Tilanus.   

Abstract

Most of the 119 human leukocyte antigen (HLA)-DPB1 alleles are defined by polymorphism in six hypervariable regions (HVRs) in exon 2 of the HLA-DPB1 gene. We investigated how DPB1 polymorphism is represented in the entire coding region. An RNA sequencing-based typing (SBT) approach was developed for the identification of HLA-DPB1 polymorphism from the 5' untranslated region (UTR) through the 3'-UTR. B-cell lymphoblastoid cell lines, encoding 16 different DPB1 alleles, were studied. Results show additional HLA-DPB1 polymorphism in exons 1, 3, 4 and 5 and the 5' and 3'-UTR. Four new HLA-DPB1 alleles were identified, DPB1*0502, DPB1*0602, DPB1*0802 and DPB1*0902, which have exon 2 sequences identical to other DPB1 alleles but differ in the extended region. The additional polymorphism represents two main polymorphic lineages in the DPB1 alleles. Among the HVRs in exon 2, only HVR F correlates with these two main lineages.

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Year:  2005        PMID： 16189666     DOI： 10.1007/s00251-005-0043-8

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  10 in total

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Journal:  Hum Immunol       Date:  2005-03-03       Impact factor: 2.850

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Journal:  J Immunol       Date:  2002-12-15       Impact factor: 5.422

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Journal:  Hum Immunol       Date:  1995-02       Impact factor: 2.850

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Journal:  Int Immunol       Date:  2003-05       Impact factor: 4.823

8.  Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen-DP polymorphism on peptide-binding specificity.

Authors:  F Berretta; R H Butler; G Diaz; N Sanarico; J Arroyo; M Fraziano; G Aichinger; K W Wucherpfennig; V Colizzi; C Saltini; M Amicosante
Journal:  Tissue Antigens       Date:  2003-12

9.  A new epitope-based HLA-DPB matching approach for cadaver kidney retransplants.

Authors:  Gunter Laux; Ulrich Mansmann; Ariane Deufel; Gerhard Opelz; Joannis Mytilineos
Journal:  Transplantation       Date:  2003-05-15       Impact factor: 4.939

10.  Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic proliferative and cytotoxic responses.

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Journal:  J Exp Med       Date:  1980-09-01       Impact factor: 14.307
  10 in total
  2 in total

1.  Genome-wide minor histocompatibility matching as related to the risk of graft-versus-host disease.

Authors:  Paul J Martin; David M Levine; Barry E Storer; Edus H Warren; Xiuwen Zheng; Sarah C Nelson; Anajane G Smith; Bo K Mortensen; John A Hansen
Journal:  Blood       Date:  2016-11-21       Impact factor: 22.113

2.  The influence of positive selection and trans-species evolution on DPB diversity in the golden snub-nosed monkeys (Rhinopithecus roxellana).

Authors:  Xiaoyue Song; Pei Zhang; Kang Huang; Dan Chen; Songtao Guo; Xiaoguang Qi; Gang He; Ruliang Pan; Baoguo Li
Journal:  Primates       Date:  2016-05-21       Impact factor: 2.163
  2 in total

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