AIMS: To register mortality and causes of death in patients with congenital heart defects (CHDs). METHODS: Prospective population-based observational study. RESULTS: 553 infants with CHD (1.1% of live born) were observed for 1-22 y (median 10 7/12 y). Sixty-four died (11.6%), of whom 32 (50%) died during the first 4 wk, and 51 (79.7%) during the first year of life. Of the total neonatal deaths in the population (3 per 1000), CHDs occurred in 21.5%. Mortality for children with CHDs was not significantly different between the cohorts born in 1982-1991 and 1992-2002, for either neonatal deaths or deaths later on (p>0.05). Out of 170 patients in whom therapeutic procedures (surgery, catheter interventions) were undertaken, 34 (20%) died. Nine cases (1.6%) died with unrecognized CHDs; seven of these on the first day of life with severe extracardiac malformations. In 50 (78.1%) cases, death was judged to be caused directly or indirectly from the CHD, and in 14 (21.9%) from extracardiac malformations or other conditions. CONCLUSION: CHDs occur in a substantial number of neonatal deaths. Most deaths are caused by cardiac insufficiency. The mortality rate remained unchanged.
AIMS: To register mortality and causes of death in patients with congenital heart defects (CHDs). METHODS: Prospective population-based observational study. RESULTS: 553 infants with CHD (1.1% of live born) were observed for 1-22 y (median 10 7/12 y). Sixty-four died (11.6%), of whom 32 (50%) died during the first 4 wk, and 51 (79.7%) during the first year of life. Of the total neonatal deaths in the population (3 per 1000), CHDs occurred in 21.5%. Mortality for children with CHDs was not significantly different between the cohorts born in 1982-1991 and 1992-2002, for either neonatal deaths or deaths later on (p>0.05). Out of 170 patients in whom therapeutic procedures (surgery, catheter interventions) were undertaken, 34 (20%) died. Nine cases (1.6%) died with unrecognized CHDs; seven of these on the first day of life with severe extracardiac malformations. In 50 (78.1%) cases, death was judged to be caused directly or indirectly from the CHD, and in 14 (21.9%) from extracardiac malformations or other conditions. CONCLUSION: CHDs occur in a substantial number of neonatal deaths. Most deaths are caused by cardiac insufficiency. The mortality rate remained unchanged.
Authors: Leslie A Frieden; Todd A Townsend; David B Vaught; Daniel M Delaughter; Yoonha Hwang; Joey V Barnett; Jin Chen Journal: Dev Dyn Date: 2010-10-19 Impact factor: 3.780
Authors: Øivind Solberg; Maria T Grønning Dale; Henrik Holmstrøm; Leif T Eskedal; Markus A Landolt; Margarete E Vollrath Journal: J Pediatr Psychol Date: 2010-06-17
Authors: Elizabeth C Ailes; Suzanne M Gilboa; Tiffany Riehle-Colarusso; Candice Y Johnson; Charlotte A Hobbs; Adolfo Correa; Margaret A Honein Journal: Prenat Diagn Date: 2013-12-17 Impact factor: 3.050