| Literature DB >> 16188326 |
Agnes Bánvölgyi1, László Pálinkás, Tímea Berki, Natalie Clark, Andrew D Grant, Zsuzsanna Helyes, Gábor Pozsgai, János Szolcsányi, Susan D Brain, Erika Pintér.
Abstract
The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.Entities:
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Year: 2005 PMID： 16188326 DOI： 10.1016/j.jneuroim.2005.08.012
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478