BACKGROUND: Clinical and dermoscopic aspects of dermatofibroma (DF) are usually typical. Systematic analysis of dermoscopic features of DFs has rarely been performed. OBJECTIVE: To evaluate the dermoscopic patterns of DFs and, in selected cases, the change of these patterns over time. METHODS: Dermoscopic examination was performed in 39 DFs belonging to 32 patients. In each case, the diagnosis was confirmed histopathologically. RESULTS: We identified the following three dermoscopic patterns: isolated presence of the pigment network in 31% of cases; a peripheral pigment network associated with either globules and dots or with scale crusts, and sometimes also with a more or less evident white patch, in the central area in 13% of cases; and a peripheral pigment network with a central white area in 56% of cases. CONCLUSION: The dermoscopic patterns observed in our case series may correspond to distinct sequential stages of formation, suggesting clues to understanding the pathogenesis of DF.
BACKGROUND: Clinical and dermoscopic aspects of dermatofibroma (DF) are usually typical. Systematic analysis of dermoscopic features of DFs has rarely been performed. OBJECTIVE: To evaluate the dermoscopic patterns of DFs and, in selected cases, the change of these patterns over time. METHODS: Dermoscopic examination was performed in 39 DFs belonging to 32 patients. In each case, the diagnosis was confirmed histopathologically. RESULTS: We identified the following three dermoscopic patterns: isolated presence of the pigment network in 31% of cases; a peripheral pigment network associated with either globules and dots or with scale crusts, and sometimes also with a more or less evident white patch, in the central area in 13% of cases; and a peripheral pigment network with a central white area in 56% of cases. CONCLUSION: The dermoscopic patterns observed in our case series may correspond to distinct sequential stages of formation, suggesting clues to understanding the pathogenesis of DF.
Authors: Zahra Turani; Emad Fatemizadeh; Tatiana Blumetti; Steven Daveluy; Ana Flavia Moraes; Wei Chen; Darius Mehregan; Peter E Andersen; Mohammadreza Nasiriavanaki Journal: Cancer Res Date: 2019-02-18 Impact factor: 12.701