Literature DB >> 16187786

A longitudinal study of operant responding in rats irradiated when 2 months old.

Bernard M Rabin1, James A Joseph, Barbara Shukitt-Hale.   

Abstract

Two-month-old rats were exposed to 56Fe particles (1, 1.5, 2 Gy; 1 GeV/nucleon). They were tested on the performance of an ascending fixed-ratio operant task (bar pressing for food reward) at 7, 11 and 15 months after irradiation. Previous research had shown that for the same rats tested at 3 months after exposure, only the rats exposed to 2 Gy of 56Fe particles showed a significant disruption of performance compared to control (0 Gy) rats. When these rats were tested 7, 11 and 15 months after exposure, all irradiated groups showed significantly poorer performance than the controls. These results suggest that there is an interaction between irradiation and age such that 56Fe-particle-induced performance deficits can develop several months after exposure.

Entities:  

Keywords:  NASA Discipline Radiation Health; Non-NASA Center

Mesh：

Substances：

Year:  2005        PMID： 16187786     DOI： 10.1667/rr3349.1

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  11 in total

1.  Interaction between age of irradiation and age of testing in the disruption of operant performance using a ground-based model for exposure to cosmic rays.

Authors:  Bernard M Rabin; James A Joseph; Barbara Shukitt-Hale; Kirsty L Carrihill-Knoll
Journal:  Age (Dordr)       Date:  2011-03-22

Review 2.  MicroPET investigation of chronic long-term neurotoxicity from heavy ion irradiation.

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Journal:  AAPS J       Date:  2006-08-04       Impact factor: 4.009

3.  Effect of diet on the disruption of operant responding at different ages following exposure to (56)Fe particles.

Authors:  Bernard M Rabin; Kirsty L Carrihill-Knoll; Amanda Carey; Barbara Shukitt-Hale; James A Joseph
Journal:  Age (Dordr)       Date:  2005-05-02

4.  Amphetamine-induced taste aversion learning in young and old F-344 rats following exposure to 56Fe particles.

Authors:  K L Carrihill-Knoll; B M Rabin; B Shukitt-Hale; J A Joseph; A Carey
Journal:  Age (Dordr)       Date:  2007-05-03

5.  Long-term effects of irradiation with iron-56 particles on the nigrostriatal dopamine system.

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Journal:  Radiat Environ Biophys       Date:  2009-03-04       Impact factor: 1.925

6.  Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production.

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7.  Deficits in Sustained Attention and Changes in Dopaminergic Protein Levels following Exposure to Proton Radiation Are Related to Basal Dopaminergic Function.

Authors:  Catherine M Davis; Kathleen L DeCicco-Skinner; Robert D Hienz
Journal:  PLoS One       Date:  2015-12-10       Impact factor: 3.240

Review 8.  Central Nervous System Responses to Simulated Galactic Cosmic Rays.

Authors:  Egle Cekanaviciute; Susanna Rosi; Sylvain V Costes
Journal:  Int J Mol Sci       Date:  2018-11-20       Impact factor: 5.923

9.  Effects of X-ray radiation on complex visual discrimination learning and social recognition memory in rats.

Authors:  Catherine M Davis; Peter G Roma; Elwood Armour; Virginia L Gooden; Joseph V Brady; Michael R Weed; Robert D Hienz
Journal:  PLoS One       Date:  2014-08-06       Impact factor: 3.240

10.  Whole-Body 12C Irradiation Transiently Decreases Mouse Hippocampal Dentate Gyrus Proliferation and Immature Neuron Number, but Does Not Change New Neuron Survival Rate.

Authors:  Giulia Zanni; Hannah M Deutsch; Phillip D Rivera; Hung-Ying Shih; Junie A LeBlanc; Wellington Z Amaral; Melanie J Lucero; Rachel L Redfield; Matthew J DeSalle; Benjamin P C Chen; Cody W Whoolery; Ryan P Reynolds; Sanghee Yun; Amelia J Eisch
Journal:  Int J Mol Sci       Date:  2018-10-09       Impact factor: 5.923
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