Literature DB >> 16186924

Efficient terpene hydroxylation catalysts based upon P450 enzymes derived from actinomycetes.

Ayhan Celik1, Sabine L Flitsch, Nicholas J Turner.   

Abstract

The hydroxylation of alpha-ionone 1 and beta-ionone 2 to their corresponding mono-hydroxylated derivatives has been examined using a recombinant E. coli whole cell system, in which cytochromes P450 SU1 and SU2, and P450 SOY were over-expressed with their cognate ferrodoxins. Both substrates are hydroxylated with a high degree of regioselectivity and for alpha-ionone 1 the reaction is highly diastereoselective yielding the anti-isomer.

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Year:  2005        PMID： 16186924     DOI： 10.1039/b506159h

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  3 in total

1.  Regioselective biooxidation of (+)-valencene by recombinant E. coli expressing CYP109B1 from Bacillus subtilis in a two-liquid-phase system.

Authors:  Marco Girhard; Kazuhiro Machida; Masashi Itoh; Rolf D Schmid; Akira Arisawa; Vlada B Urlacher
Journal:  Microb Cell Fact       Date:  2009-07-10       Impact factor: 5.328

2.  Regio- and stereoselective oxidation of unactivated C-H bonds with Rhodococcus rhodochrous.

Authors:  Elaine O'Reilly; Suzanne J Aitken; Gideon Grogan; Paul P Kelly; Nicholas J Turner; Sabine L Flitsch
Journal:  Beilstein J Org Chem       Date:  2012-04-03       Impact factor: 2.883

3.  Elucidation of the regio- and chemoselectivity of enzymatic allylic oxidations with Pleurotus sapidus - conversion of selected spirocyclic terpenoids and computational analysis.

Authors:  Verena Weidmann; Mathias Schaffrath; Holger Zorn; Julia Rehbein; Wolfgang Maison
Journal:  Beilstein J Org Chem       Date:  2013-10-29       Impact factor: 2.883
  3 in total

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