Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development.

Literature DB >> 16186692

The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development.

Uwe Knippschild¹, Sonja Wolff, Georgios Giamas, Claas Brockschmidt, Mathias Wittau, Peter Uwe Würl, Thorsten Eismann, Martin Stöter.

Abstract

The members of the casein kinase 1 (CK1) family are highly conserved and are expressed in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Mutations and deregulation of CK1 expression and activity has been linked to various diseases including neurodegenerative disorders such as Alzheimer's and Parkinson's disease, sleeping disorders and proliferative diseases such as cancer. In this review, we summarize the functions of CK1 and outline the participation of CK1 in signal transduction pathways linked to cancer development.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16186692 DOI： 10.1159/000087137

Source DB: PubMed Journal: Onkologie ISSN： 0378-584X

Keyword Cloud
Cited

54 in total

1. kin-19/casein kinase Iα has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells.

Authors: Diya Banerjee; Xin Chen; Shin Yi Lin; Frank J Slack
Journal: Cell Cycle Date: 2010-12-01 Impact factor: 4.534

2. A population-based association study of casein kinase 1 epsilon loci with heroin dependence in Han Chinese.

Authors: Yunpeng Wang; Yongsheng Zhu; Wei Wang; Feng Wu; Haimin Cui; Xi Xun; Jianghua Lai
Journal: J Mol Neurosci Date: 2013-12-17 Impact factor: 3.444

3. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

Authors: Carrie L Partch; Katherine F Shields; Carol L Thompson; Christopher P Selby; Aziz Sancar
Journal: Proc Natl Acad Sci U S A Date: 2006-06-21 Impact factor: 11.205

4. The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.

Authors: Katherine S Godin; Hélène Walbott; Nicolas Leulliot; Herman van Tilbeurgh; Gabriele Varani
Journal: J Mol Biol Date: 2009-05-06 Impact factor: 5.469

The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development.

1. kin-19/casein kinase Iα has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells.

2. A population-based association study of casein kinase 1 epsilon loci with heroin dependence in Han Chinese.

3. Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

4. The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.

5. Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition.

6. Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.

7. CSNK1α1 mediates malignant plasma cell survival.

8. Partitioning of casein kinase 1-like 6 to late endosome-like vesicles.

Review 9. An evolving role for DEPTOR in tumor development and progression.

10. Anticancer alkaloid lamellarins inhibit protein kinases.