OBJECTIVE: The present study was designed to assess the effect of magnesium plus zinc, vitamins C plus E, and a combination of these micronutrients on nephropathy indexes in type 2 diabetic patients. RESEARCH DESIGN AND METHODS: In a randomized, double-blind, placebo-controlled clinical trial, 69 type 2 diabetic patients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months: group M (n = 16), 200 mg Mg and 30 mg Zn; group V (n = 18), 200 mg vitamin C and 100 IU vitamin E; group MV (n = 17), minerals plus vitamins; and group P (n = 18), placebo. Urinary albumin excretion and N-acetyl-beta-d-glucosaminidase activity (NAG) in urine were determined at the beginning and at the end of the trial. Treatment effects were analyzed by general linear modeling. RESULTS: Results indicate that after 3 months of supplementation, levels of urinary albumin excretion decreased in the V and MV groups (P = 0.034 and P = 0.005, respectively). Urinary NAG activity did not significantly change in any treatment groups. Levels of systolic, diastolic, and mean blood pressure significantly decreased in the MV group (P = 0.008, P = 0.017, and P = 0.009, respectively). Also, combination of vitamin and mineral supplementation had significant effects in decreasing fasting serum glucose (P = 0.035) and malondialdehyde concentrations (P = 0.004) and in increasing HDL cholesterol and apolipoprotein A1 levels (P = 0.019). There was no significant change in the levels of these parameters in the other three groups. CONCLUSIONS: In conclusion, the results of the present study provide evidence for the effects of vitamins C and E and also combination of magnesium, zinc, and vitamins C and E supplementation on improvement of glomerular but not tubular renal function in type 2 diabetic patients.
RCT Entities:
OBJECTIVE: The present study was designed to assess the effect of magnesium plus zinc, vitamins C plus E, and a combination of these micronutrients on nephropathy indexes in type 2 diabeticpatients. RESEARCH DESIGN AND METHODS: In a randomized, double-blind, placebo-controlled clinical trial, 69 type 2 diabeticpatients were randomly divided into four groups, each group receiving one of the following daily supplement for 3 months: group M (n = 16), 200 mg Mg and 30 mg Zn; group V (n = 18), 200 mg vitamin C and 100 IU vitamin E; group MV (n = 17), minerals plus vitamins; and group P (n = 18), placebo. Urinary albumin excretion and N-acetyl-beta-d-glucosaminidase activity (NAG) in urine were determined at the beginning and at the end of the trial. Treatment effects were analyzed by general linear modeling. RESULTS: Results indicate that after 3 months of supplementation, levels of urinary albumin excretion decreased in the V and MV groups (P = 0.034 and P = 0.005, respectively). Urinary NAG activity did not significantly change in any treatment groups. Levels of systolic, diastolic, and mean blood pressure significantly decreased in the MV group (P = 0.008, P = 0.017, and P = 0.009, respectively). Also, combination of vitamin and mineral supplementation had significant effects in decreasing fasting serum glucose (P = 0.035) and malondialdehyde concentrations (P = 0.004) and in increasing HDL cholesterol and apolipoprotein A1 levels (P = 0.019). There was no significant change in the levels of these parameters in the other three groups. CONCLUSIONS: In conclusion, the results of the present study provide evidence for the effects of vitamins C and E and also combination of magnesium, zinc, and vitamins C and E supplementation on improvement of glomerular but not tubular renal function in type 2 diabeticpatients.
Authors: Heather A Anaya; Fu-Xian Yi; Derek S Boeldt; Jennifer Krupp; Mary A Grummer; Dinesh M Shah; Ian M Bird Journal: Biol Reprod Date: 2015-07-22 Impact factor: 4.285
Authors: Niina Sandholm; Natalie Van Zuydam; Emma Ahlqvist; Thorhildur Juliusdottir; Harshal A Deshmukh; N William Rayner; Barbara Di Camillo; Carol Forsblom; Joao Fadista; Daniel Ziemek; Rany M Salem; Linda T Hiraki; Marcus Pezzolesi; David Trégouët; Emma Dahlström; Erkka Valo; Nikolay Oskolkov; Claes Ladenvall; M Loredana Marcovecchio; Jason Cooper; Francesco Sambo; Alberto Malovini; Marco Manfrini; Amy Jayne McKnight; Maria Lajer; Valma Harjutsalo; Daniel Gordin; Maija Parkkonen; Jaakko Tuomilehto; Valeriya Lyssenko; Paul M McKeigue; Stephen S Rich; Mary Julia Brosnan; Eric Fauman; Riccardo Bellazzi; Peter Rossing; Samy Hadjadj; Andrzej Krolewski; Andrew D Paterson; Jose C Florez; Joel N Hirschhorn; Alexander P Maxwell; David Dunger; Claudio Cobelli; Helen M Colhoun; Leif Groop; Mark I McCarthy; Per-Henrik Groop Journal: J Am Soc Nephrol Date: 2016-09-19 Impact factor: 10.121