OBJECTIVE: Among Europeans, mutations in the hepatocyte nuclear factor-1alpha (HNF1alpha) gene are associated with the most common form of maturity-onset diabetes of the young (MODY)3. In Asian Indians, type 2 diabetes occurs earlier and often overlaps with MODY, but the genetics of the latter are unknown. The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians. RESEARCH DESIGN AND METHODS: Genotyping of Ala98Val was done by the PCR-restriction fragment-length polymorphism method in the following groups: 1) MODY, defined as non-insulin-dependent diabetes (age at onset <25 years) and vertical transmission of diabetes through at least three generations (n = 122); 2) very-early-onset type 2 diabetes (age at onset <25 years) without family history (n = 23); 3) early-onset type 2 diabetes (age at onset between 26 and 40 years, n = 171); 4) late-onset type 2 diabetes (age at onset >40 years, n = 133); 5) type 1 diabetes (n = 150); and 6) normal glucose tolerance (n = 130). The frequency of the Val genotypes was compared in the diabetic and control groups. RESULTS: The frequency of the Val allele was significantly higher in MODY patients (P = 0.0013) compared with control groups. Furthermore, in the total group of patients with type 2-like diabetes (groups 1-4), the Val allele was associated with an earlier diagnosis of diabetes (P = 0.0002). CONCLUSIONS: Among Asian Indians, the Ala98Val polymorphism of HNF1alpha gene is associated with MODY and with earlier age at onset of type 2 diabetes.
OBJECTIVE: Among Europeans, mutations in the hepatocyte nuclear factor-1alpha (HNF1alpha) gene are associated with the most common form of maturity-onset diabetes of the young (MODY)3. In Asian Indians, type 2 diabetes occurs earlier and often overlaps with MODY, but the genetics of the latter are unknown. The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians. RESEARCH DESIGN AND METHODS: Genotyping of Ala98Val was done by the PCR-restriction fragment-length polymorphism method in the following groups: 1) MODY, defined as non-insulin-dependent diabetes (age at onset <25 years) and vertical transmission of diabetes through at least three generations (n = 122); 2) very-early-onset type 2 diabetes (age at onset <25 years) without family history (n = 23); 3) early-onset type 2 diabetes (age at onset between 26 and 40 years, n = 171); 4) late-onset type 2 diabetes (age at onset >40 years, n = 133); 5) type 1 diabetes (n = 150); and 6) normal glucose tolerance (n = 130). The frequency of the Val genotypes was compared in the diabetic and control groups. RESULTS: The frequency of the Val allele was significantly higher in MODY patients (P = 0.0013) compared with control groups. Furthermore, in the total group of patients with type 2-like diabetes (groups 1-4), the Val allele was associated with an earlier diagnosis of diabetes (P = 0.0002). CONCLUSIONS: Among Asian Indians, the Ala98Val polymorphism of HNF1alpha gene is associated with MODY and with earlier age at onset of type 2 diabetes.
Authors: Pushplata Prasad; Arun K Tiwari; K M Prasanna Kumar; A C Ammini; Arvind Gupta; Rajeev Gupta; A K Sharma; A R Rao; R Nagendra; T Satish Chandra; S C Tiwari; Priyanka Rastogi; B Lal Gupta; B K Thelma Journal: BMC Med Genet Date: 2006-05-03 Impact factor: 2.103
Authors: Viswanathan Mohan; Venkatesan Radha; Thong T Nguyen; Eric W Stawiski; Kanika Bajaj Pahuja; Leonard D Goldstein; Jennifer Tom; Ranjit Mohan Anjana; Monica Kong-Beltran; Tushar Bhangale; Suresh Jahnavi; Radhakrishnan Chandni; Vijay Gayathri; Paul George; Na Zhang; Sakthivel Murugan; Sameer Phalke; Subhra Chaudhuri; Ravi Gupta; Jingli Zhang; Sam Santhosh; Jeremy Stinson; Zora Modrusan; V L Ramprasad; Somasekar Seshagiri; Andrew S Peterson Journal: BMC Med Genet Date: 2018-02-13 Impact factor: 2.103
Authors: Fernando M A Giuffrida; Gilberto K Furuzawa; Teresa S Kasamatsu; Marcos M Oliveira; Andre F Reis; Sergio A Dib Journal: Cardiovasc Diabetol Date: 2009-06-02 Impact factor: 9.951