Literature DB >> 16185877

Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile.

George N Ziakas1, Eleni A Rekka, Antonios M Gavalas, Phaedra T Eleftheriou, Karyofillis C Tsiakitzis, Panos N Kourounakis.   

Abstract

Tolfenamic acid esters with nitrooxyalcohols are synthesized. They are anti-inflammatory agents reducing carrageenan rat paw edema, with low gastrointestinal and general toxicity. In vitro, they are nitric oxide donors, inhibitors of lipoxygenase and cyclooxygenases. A two to three carbon chain between carboxylic and nitric ester groups seems optimal for activity.

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Year:  2005        PMID： 16185877     DOI： 10.1016/j.bmc.2005.07.049

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.

Authors:  Zhihui Qin; Jia Luo; Lawren VandeVrede; Ehsan Tavassoli; Mauro Fa'; Andrew F Teich; Ottavio Arancio; Gregory R J Thatcher
Journal:  J Med Chem       Date:  2012-07-24       Impact factor: 7.446

2.  Synthesis and evaluation of antiinflammatory, analgesic and ulcerogenic potential of NSAIDs bearing 1,3,4-oxadiazole scaffold.

Authors:  R R Somani; U V Bhanushali
Journal:  Indian J Pharm Sci       Date:  2011-11       Impact factor: 0.975

3.  Design, Synthesis and Study of Nitrogen Monoxide Donors as Potent Hypolipidaemic and Anti-Inflammatory Agents.

Authors:  Panagiotis Theodosis-Nobelos; Georgios Papagiouvanis; Maria Pantelidou; Panos N Kourounakis; Chrysoula Athanasekou; Eleni A Rekka
Journal:  Molecules       Date:  2019-12-19       Impact factor: 4.411
  3 in total

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