| Literature DB >> 16185865 |
Rolf Wagner1, Karl W Mollison, Luping Liu, Cynthia L Henry, Teresa A Rosenberg, Nwe Bamaung, Noah Tu, Paul E Wiedeman, Yatsun Or, Jay R Luly, Benjamin C Lane, James Trevillyan, Yung-Wu Chen, Thomas Fey, Gin Hsieh, Kennan Marsh, Merrill Nuss, Peer B Jacobson, Denise Wilcox, Richard P Carlson, George W Carter, Stevan W Djuric.
Abstract
The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.Entities:
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Year: 2005 PMID： 16185865 DOI： 10.1016/j.bmcl.2005.06.106
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823