| Literature DB >> 16185241 |
Sedigheh Zakeri1, Sándor Bereczky, Parin Naimi, J Pedro Gil, Navid Dinparast Djadid, Anna Färnert, Georges Snounou, Anders Björkman.
Abstract
In Iran, malaria transmission mainly occurs in south-eastern regions through both Plasmodium falciparum and P. vivax. The genetic diversity of P. falciparum isolates was analysed in 108 patients attending the regional hospital in Chabahar District, using the molecular markers msp1 and msp2. Multiple genotypes were detected in 87% of patients and the mean numbers of msp1 and msp2 genotypes were 2.51 (95% CI: 2.29-2.73) and 2.61 (95% CI: 2.39-2.83) respectively. Various allelic types of msp1 and msp2 were found, with msp2 3D7/IC type detected in 94% of infections. Plasmodium falciparum infections in south-east Iran appear to have a higher genetic diversity than expected for an area of low transmission. A situation of higher transmission in this area may be emerging, possibly because of reduced efficacy of first-line treatments.Entities:
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Year: 2005 PMID： 16185241 DOI： 10.1111/j.1365-3156.2005.01477.x
Source DB: PubMed Journal: Trop Med Int Health ISSN： 1360-2276 Impact factor: 2.622