OBJECTIVE: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. METHODS: Population based case-control study nested in a cohort. RESULTS: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas. CONCLUSION: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.
OBJECTIVE: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. METHODS: Population based case-control study nested in a cohort. RESULTS: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabeticpatients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas. CONCLUSION:Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.
Authors: Ilir Agalliu; Miia Suuriniemi; Ludmila Prokunina-Olsson; Bo Johanneson; Francis S Collins; Janet L Stanford; Elaine A Ostrander Journal: Prostate Date: 2008-05-15 Impact factor: 4.104
Authors: Jakob Starup-Linde; Oystein Karlstad; Stine Aistrup Eriksen; Peter Vestergaard; Heleen K Bronsveld; Frank de Vries; Morten Andersen; Anssi Auvinen; Jari Haukka; Vidar Hjellvik; Marloes T Bazelier; Anthonius de Boer; Kari Furu; Marie L De Bruin Journal: Curr Drug Saf Date: 2013-11