| Literature DB >> 16184046 |
Tricia H Burdo1, Maria Cecilia G Marcondes, Caroline M S Lanigan, Maria Cecilia T Penedo, Howard S Fox.
Abstract
The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.Entities:
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Year: 2005 PMID: 16184046 DOI: 10.1097/01.aids.0000186823.76230.33
Source DB: PubMed Journal: AIDS ISSN: 0269-9370 Impact factor: 4.177