Literature DB >> 16184043

Evaluation of the anti-HIV activity of statins.

Gemma Moncunill1, Eugenia Negredo, Lluís Bosch, Jaume Vilarrasa, Myriam Witvrouw, Anuska Llano, Bonaventura Clotet, José A Esté.   

Abstract

Recent data suggest that statins block HIV-1 replication, which may have important implications for an alternative treatment for AIDS. We tested different statins in cell culture against HIV and conducted a pilot study in HIV-positive patients receiving simvastatin. No anti-HIV activity was detected at subtoxic concentrations and simvastatin did not induce a significant change in the mean viral load or CD4 cell count in study patients. We caution on the use of statins as antiretroviral agents.

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Year:  2005        PMID： 16184043     DOI： 10.1097/01.aids.0000183517.60384.db

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  23 in total

1.  The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system.

Authors:  Scott L Letendre; Jennifer Marquie-Beck; Ronald J Ellis; Steven Paul Woods; Brookie Best; David B Clifford; Ann C Collier; Benjamin B Gelman; Christina Marra; Justin C McArthur; J Allen McCutchan; Susan Morgello; David Simpson; Terry J Alexander; Janis Durelle; Robert Heaton; Igor Grant
Journal:  J Neuroimmune Pharmacol       Date:  2007-01-03       Impact factor: 4.147

Review 2.  Novel approaches to inhibiting HIV-1 replication.

Authors:  Catherine S Adamson; Eric O Freed
Journal:  Antiviral Res       Date:  2009-09-24       Impact factor: 5.970

3.  Statins as anti-inflammatory therapy in HIV disease?

Authors:  Andrew Carr
Journal:  J Infect Dis       Date:  2011-01-25       Impact factor: 5.226

Review 4.  The role of statins in the setting of HIV infection.

Authors:  Allison Ross Eckard; Grace A McComsey
Journal:  Curr HIV/AIDS Rep       Date:  2015-09       Impact factor: 5.071

Review 5.  Understanding and controlling chronic immune activation in the HIV-infected patients suppressed on combination antiretroviral therapy.

Authors:  Babafemi Taiwo; Luis Barcena; Randall Tressler
Journal:  Curr HIV/AIDS Rep       Date:  2013-03       Impact factor: 5.071

6.  Low cholesterol? Don't brag yet ... hypocholesterolemia blunts HAART effectiveness: a longitudinal study.

Authors:  María Jose Míguez; John E Lewis; Vaughn E Bryant; Rhonda Rosenberg; Ximena Burbano; Joel Fishman; Deshratn Asthana; Rui Duan; Nair Madhavan; Robert M Malow
Journal:  J Int AIDS Soc       Date:  2010-07-13       Impact factor: 5.396

7.  Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells.

Authors:  Ibolya E András; Geunbae Rha; Wen Huang; Sungyong Eum; Pierre-Olivier Couraud; Ignacio A Romero; Bernhard Hennig; Michal Toborek
Journal:  Mol Pharmacol       Date:  2008-02-14       Impact factor: 4.436

Review 8.  Lipids and membrane microdomains in HIV-1 replication.

Authors:  Abdul A Waheed; Eric O Freed
Journal:  Virus Res       Date:  2009-04-19       Impact factor: 3.303

9.  The Role of Lipids in Retrovirus Replication.

Authors:  Abdul A Waheed; Eric O Freed
Journal:  Viruses       Date:  2010-05-01       Impact factor: 5.048

10.  Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial.

Authors:  Carlos J Montoya; Fabian Jaimes; Edwin A Higuita; Sandra Convers-Páez; Santiago Estrada; Francisco Gutierrez; Pedro Amariles; Newar Giraldo; Cristina Peñaloza; Maria T Rugeles
Journal:  Trials       Date:  2009-06-18       Impact factor: 2.279
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