Literature DB >> 1618301

Group II phospholipase A2 induced by interleukin-1 beta in cultured rat gingival fibroblasts.

H Shinohara1, Y Amabe, T Komatsubara, H Tojo, M Okamoto, Y Wakano, H Ishida.   

Abstract

Previously, we reported the presence of group II-like phospholipase A2 activity in the soluble fraction of rat gingiva. In the present study, we found that treatment of rat gingival cells with human recombinant interleukin-1 beta resulted in dose-dependent stimulation of intracellular and extracellular phospholipase A2 activity. Antisera against group II phospholipase A2 totally blocked the interleukin-1 beta-induced phospholipase A2 activity, but antisera against group I phospholipase A2 did not. Moreover, immunoblot analysis showed that the induced phospholipase A2 was group II phospholipase A2. These findings suggest that the induced enzyme belongs to the group II phospholipase A2 family of proinflammatory enzymes.

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Year:  1992        PMID： 1618301     DOI： 10.1016/0014-5793(92)80591-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Effects of IL-1 beta on receptor-mediated poly-phosphoinositide signaling pathway in immortalized astrocytes (DITNC).

Authors:  J M Wu; G Y Sun
Journal:  Neurochem Res       Date:  1997-10       Impact factor: 3.996

2.  Mechanisms of prostanoid synthesis in human synovial cells: cytokine-peptide synergism.

Authors:  J M Bathon; F H Chilton; W C Hubbard; M C Towns; N J Solan; D Proud
Journal:  Inflammation       Date:  1996-10       Impact factor: 4.092

3.  Effects of endotoxin and dexamethasone on group I and II phospholipase A2 in rat ileum and stomach.

Authors:  I Lilja; J Dimberg; R Sjödahl; C Tagesson; C Gustafson-Svärd
Journal:  Gut       Date:  1994-01       Impact factor: 23.059

Review 4.  Role of secretory phospholipase a(2) in CNS inflammation: implications in traumatic spinal cord injury.

Authors:  W Lee Titsworth; Nai-Kui Liu; Xiao-Ming Xu
Journal:  CNS Neurol Disord Drug Targets       Date:  2008-06       Impact factor: 4.388

5.  Phospholipase A(2) Activity in Gingival Crevicular Fluid from Patients with Periodontal Disease: A possible Marker of Disease Activity.

Authors:  H Ishida; H Shinohara; T Nagata; S Nishikawa; Y Wakano
Journal:  Mediators Inflamm       Date:  1994       Impact factor: 4.711

6.  Group II phospholipase A(2) in human gingiva with periodontal disease.

Authors:  H Shinohara; T Komatsubara; H Tojo; M Okamoto; S Nishikawa; T Nagata; H Ishida
Journal:  Mediators Inflamm       Date:  1995       Impact factor: 4.711
  6 in total

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