AIM: To evaluate factors affecting patient and kidney survival after renal transplant. PATIENT AND METHODS: Among 361 patients undergoing renal transplant: 52% (n = 189) were simultaneous with pancreas transplant (SPKT group) and 48% (n = 172), a kidney transplant alone (KT group). Out of 361 patients, 75% (n = 270) were diabetics. The patients were 220 (61%) men and 141 (39%) women of mean age 41 +/- 9 years. The mean time of dialysis was 42 +/- 21 months (range 0 to 126), and the mean duration of diabetes 24 +/- 7 years (range 5 to 51). A Cox regression analysis was done. RESULTS: The multivariate analysis revealed that in the final model diabetes and donor age were significant predictors of kidney graft survival; moreover, diabetes and recipient age were predictors of patient survival. Overall patient survival was significantly greater among nondiabetic patients (P = .002) or in diabetic patients who received SPKT, when compared with diabetics in whom only the kidney was transplanted (P = .001). CONCLUSIONS: Diabetes and donor age were independent prognostic factors affecting kidney graft survival after renal transplant, and recipient age and diabetes were prognostic factors affecting patient survival. Combined pancreas and kidney transplantation should be offered to patients with end-stage diabetic nephropathy.
AIM: To evaluate factors affecting patient and kidney survival after renal transplant. PATIENT AND METHODS: Among 361 patients undergoing renal transplant: 52% (n = 189) were simultaneous with pancreas transplant (SPKT group) and 48% (n = 172), a kidney transplant alone (KT group). Out of 361 patients, 75% (n = 270) were diabetics. The patients were 220 (61%) men and 141 (39%) women of mean age 41 +/- 9 years. The mean time of dialysis was 42 +/- 21 months (range 0 to 126), and the mean duration of diabetes 24 +/- 7 years (range 5 to 51). A Cox regression analysis was done. RESULTS: The multivariate analysis revealed that in the final model diabetes and donor age were significant predictors of kidney graft survival; moreover, diabetes and recipient age were predictors of patient survival. Overall patient survival was significantly greater among nondiabeticpatients (P = .002) or in diabeticpatients who received SPKT, when compared with diabetics in whom only the kidney was transplanted (P = .001). CONCLUSIONS:Diabetes and donor age were independent prognostic factors affecting kidney graft survival after renal transplant, and recipient age and diabetes were prognostic factors affecting patient survival. Combined pancreas and kidney transplantation should be offered to patients with end-stage diabetic nephropathy.
Authors: Lionel Rostaing; Hans H Neumayer; Rafael Reyes-Acevedo; Barbara Bresnahan; Sander Florman; Stefan Vitko; Michael Heifets; Jun Xing; Dolca Thomas; Flavio Vincenti Journal: Clin J Am Soc Nephrol Date: 2011-09-15 Impact factor: 8.237
Authors: Javier Barba; Jorge Rioja; José Enrique Robles; Anibal Rincón; David Rosell; Juan Javier Zudaire; José María Berian; Ignacio Pascual; Alberto Benito; Pedro Errasti Journal: World J Urol Date: 2011-03-09 Impact factor: 4.226
Authors: J Hassanzadeh; A A Hashiani; A Rajaeefard; H Salahi; E Khedmati; F Kakaei; S Nikeghbalian; A Malek-Hossein Journal: Indian J Nephrol Date: 2010-10
Authors: A Almasi-Hashiani; A R Rajaeefard; J Hassanzade; H Salahi; S Nikeghbalian; P Janghorban; S A Malek-Hosseini Journal: Iran Red Crescent Med J Date: 2011-06-01 Impact factor: 0.611