| Literature DB >> 16182538 |
Lucia Rackova1, Silvia Firakova, Daniela Kostalova, Milan Stefek, Ernest Sturdik, Magdalena Majekova.
Abstract
Antioxidant activity of the set of 12 flavonoids in heterogeneous membrane system of dioleoyl phosphatidylcholine liposomes stressed by peroxidative damage induced by 2,2'-azobis-(2-amidinopropane)hydrochloride azoiniciator and evaluated by the thiocyanate method was assessed. Antioxidant activity (pIC(50)) was correlated with 19 molecule parameters calculated for the minimum energy conformers of the compounds tested. The linear regression analysis revealed that the parameter of hydration energy E(HYDR) (R = -0.747) was the best predictor of antioxidant activity in a liposomal system.Entities:
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Year: 2005 PMID： 16182538 DOI： 10.1016/j.bmc.2005.07.047
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641