Literature DB >> 16182411

Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors.

Qiong Shen1, Quan Peng, Jialiang Shao, Xufeng Liu, Zhishu Huang, Xianzhang Pu, Lin Ma, Yue-Ming Li, Albert S C Chan, Lianquan Gu.   

Abstract

Three series of functionalized coumarin compounds were designed and prepared as cholinesterase (AChE and BuChE) inhibitors. The biological profile against AChE and BuChE of the prepared compounds was determined. Compound 7b exhibited a mixed-type of AChE inhibitor with IC50 value for the AChE inhibition of 0.19+/-0.01 microM and a high selectivity for AChE/BuChE, and compound 6b acted as non-competitive AChE inhibitor with IC50 value of 0.43+/-0.02 microM. Structure-activity relationships (SARs) of prepared compounds were discussed.

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Year:  2005        PMID： 16182411     DOI： 10.1016/j.ejmech.2005.07.014

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  11 in total

1.  Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer's disease agents.

Authors:  Sheunopa C Mzezewa; Sylvester I Omoruyi; Luke S Zondagh; Sarel F Malan; Okobi E Ekpo; Jacques Joubert
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

2.  The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory.

Authors:  A Hornick; A Lieb; N P Vo; J M Rollinger; H Stuppner; H Prast
Journal:  Neuroscience       Date:  2011-09-10       Impact factor: 3.590

3.  Biological Activities and Composition of Ferulago carduchorum Essential Oil.

Authors:  Fereshteh Golfakhrabadi; Mahnaz Khanavi; Seyed Nasser Ostad; Soodabeh Saeidnia; Hassan Vatandoost; Mohammad Reza Abai; Mitra Hafizi; Fatemeh Yousefbeyk; Yaghoob Razzaghi Rad; Ameneh Baghenegadian; Mohammad Reza Shams Ardekani
Journal:  J Arthropod Borne Dis       Date:  2014-07-16       Impact factor: 1.198

4.  Antioxidant and Antiacetylcholinesterase Activity of Teucrium hyrcanicum.

Authors:  Fereshteh Golfakhrabadi; Fatemeh Yousefbeyk; Tahmineh Mirnezami; Pedram Laghaei; Mannan Hajimahmoodi; Mahnaz Khanavi
Journal:  Pharmacognosy Res       Date:  2015-06

5.  Novel Furocoumarin Derivatives Stimulate Melanogenesis in B16 Melanoma Cells by Up-Regulation of MITF and TYR Family via Akt/GSK3β/β-Catenin Signaling Pathways.

Authors:  Chao Niu; Li Yin; Haji Akber Aisa
Journal:  Int J Mol Sci       Date:  2018-03-06       Impact factor: 5.923

6.  Coumarin derivatives as acetyl- and butyrylcholinestrase inhibitors: An in vitro, molecular docking, and molecular dynamics simulations study.

Authors:  Marwa N Abu-Aisheh; Amal Al-Aboudi; Mohammad S Mustafa; Mustafa M El-Abadelah; Saman Yousuf Ali; Zaheer Ul-Haq; Mohammad S Mubarak
Journal:  Heliyon       Date:  2019-04-28

Review 7.  Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer's disease.

Authors:  Samina Khan Yusufzai; Mohammad Shaheen Khan; Othman Sulaiman; Hasnah Osman; Dalily Nabilah Lamjin
Journal:  Chem Cent J       Date:  2018-12-04       Impact factor: 4.215

8.  Preparation of novel 1,2,3-triazole furocoumarin derivatives via click chemistry and their anti-vitiligo activity.

Authors:  Chao Niu; Xueying Lu; Haji Akber Aisa
Journal:  RSC Adv       Date:  2019-01-14       Impact factor: 4.036

9.  Clausena Harmandiana root extract attenuated cognitive impairments via reducing amyloid accumulation and neuroinflammation in Aβ1-42-induced rats.

Authors:  Nutchareeporn Nillert; Chantana Boonyarat; Jariya Umka Welbat; Komsun Bunreungthong; Ploenthip Puthongking; Wanassanun Pannangrong
Journal:  BMC Complement Med Ther       Date:  2022-04-19

10.  Design, Synthesis and Antifungal Activity of Psoralen Derivatives.

Authors:  Xiang Yu; Ya Wen; Chao-Gen Liang; Jia Liu; Yu-Bin Ding; Wei-Hua Zhang
Journal:  Molecules       Date:  2017-10-09       Impact factor: 4.411
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