Literature DB >> 16180139

Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains.

Daniel L Koller1, Imranul Alam, Qiwei Sun, Lixiang Liu, Tonya Fishburn, Lucinda G Carr, Michael J Econs, Tatiana Foroud, Charles H Turner.   

Abstract

In humans, peak bone mineral density (BMD) is the primary determinant of osteoporotic fracture risk among older individuals, with high peak BMD levels providing protection against osteoporosis in the almost certain event of bone loss later in life. A genome screen to identify quantitative trait loci (QTLs) contributing to areal BMD (aBMD) and volumetric BMD (vBMD) measurements at the lumbar spine and femoral neck was completed in 595 female F2 rats produced from reciprocal crosses of inbred Fischer 344 and Lewis rats. Significant evidence of linkage was detected to rat Chromosomes 1, 2, 8, and 10, with LOD scores above 8.0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women.

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Year:  2005        PMID： 16180139     DOI： 10.1007/s00335-004-2459-0

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  21 in total

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Journal:  Genet Res       Date:  1999-12       Impact factor: 1.588

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Journal:  J Bone Miner Res       Date:  2001-08       Impact factor: 6.741

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Authors:  Yingpei Zhang; Elizabeth Chong; Brian Herman
Journal:  Exp Gerontol       Date:  2002-06       Impact factor: 4.032

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Authors:  D Marshall; O Johnell; H Wedel
Journal:  BMJ       Date:  1996-05-18

9.  MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations.

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Review 10.  Insights from the rat genome sequence.

Authors:  Linda J Mullins; John J Mullins
Journal:  Genome Biol       Date:  2004-04-30       Impact factor: 13.583
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Authors:  Imranul Alam; Daniel L Koller; Toni Cañete; Gloria Blázquez; Carme Mont-Cardona; Regina López-Aumatell; Esther Martínez-Membrives; Sira Díaz-Morán; Adolf Tobeña; Alberto Fernández-Teruel; Pernilla Stridh; Margarita Diez; Tomas Olsson; Martina Johannesson; Amelie Baud; Michael J Econs; Tatiana Foroud
Journal:  Bone       Date:  2015-08-19       Impact factor: 4.398

2.  Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass.

Authors:  John Pa Ioannidis; Mandy Y Ng; Pak C Sham; Elias Zintzaras; Cathryn M Lewis; Hong-Wen Deng; Michael J Econs; David Karasik; Marcella Devoto; Candace M Kammerer; Tim Spector; Toby Andrew; L Adrienne Cupples; Emma L Duncan; Tatiana Foroud; Douglas P Kiel; Daniel Koller; Bente Langdahl; Braxton D Mitchell; Munro Peacock; Robert Recker; Hui Shen; Katia Sol-Church; Loretta D Spotila; Andre G Uitterlinden; Scott G Wilson; Annie Wc Kung; Stuart H Ralston
Journal:  J Bone Miner Res       Date:  2007-02       Impact factor: 6.741

3.  Quantitative trait loci for BMD in an SM/J by NZB/BlNJ intercross population and identification of Trps1 as a probable candidate gene.

Authors:  Naoki Ishimori; Ioannis M Stylianou; Ron Korstanje; Michael A Marion; Renhua Li; Leah Rae Donahue; Clifford J Rosen; Wesley G Beamer; Beverly Paigen; Gary A Churchill
Journal:  J Bone Miner Res       Date:  2008-09       Impact factor: 6.741

4.  Genetic loci affecting bone structure and strength in inbred COP and DA rats.

Authors:  Qiwei Sun; Imranul Alam; Lixiang Liu; Daniel L Koller; Lucinda G Carr; Michael J Econs; Tatiana Foroud; Charles H Turner
Journal:  Bone       Date:  2007-11-28       Impact factor: 4.398

5.  Genetic determinants of osteoporosis: common bases to cardiovascular diseases?

Authors:  Francesca Marini; Maria Luisa Brandi
Journal:  Int J Hypertens       Date:  2010-03-25       Impact factor: 2.420

6.  Linkage screen for BMD phenotypes in male and female COP and DA rat strains.

Authors:  Daniel L Koller; Lixiang Liu; Imranul Alam; Qiwei Sun; Michael J Econs; Tatiana Foroud; Charles H Turner
Journal:  J Bone Miner Res       Date:  2008-09       Impact factor: 6.741

7.  Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats.

Authors:  Imranul Alam; Qiwei Sun; Daniel L Koller; Lixiang Liu; Yunlong Liu; Howard J Edenberg; Tatiana Foroud; Charles H Turner
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8.  Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men.

Authors:  Z H Al-oanzi; S P Tuck; S S Mastana; G D Summers; D B Cook; R M Francis; H K Datta
Journal:  Osteoporos Int       Date:  2007-11-24       Impact factor: 4.507

9.  Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan.

Authors:  Ilya Sabsovich; J David Clark; Guochun Liao; Gary Peltz; Derek P Lindsey; Christopher R Jacobs; Wei Yao; Tian-Zhi Guo; Wade S Kingery
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10.  Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats.

Authors:  Daniel L Koller; Lixiang Liu; Imranul Alam; Qiwei Sun; Michael J Econs; Tatiana Foroud; Charles H Turner
Journal:  J Bone Miner Res       Date:  2008-01       Impact factor: 6.741
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