OBJECTIVE: To evaluate the relationship between presurgical levels of cardiac vagal tone and outcome in neurosurgical patients. DESIGN: Prospective series. SETTING: Respiratory ICU in a university hospital. PATIENTS: Fifty-one adults admitted to the respiratory ICU between 1982 and 1985. Forty-two patients were scheduled for elective neurosurgery, and nine patients suffered from head trauma. INTERVENTIONS: Ten minutes of electrocardiographic (EKG) data were recorded before medical intervention. Neurosurgical patients scheduled for surgery had EKG data recorded 24 hrs before their operation. Trauma patients had EKG data recorded immediately after arrival in the respiratory ICU. MEASUREMENTS AND MAIN RESULTS: Cardiac vagal tone was evaluated using a vagal tone index, quantified from the EKG. Cardiac vagal tone monitored before surgical intervention significantly distinguished between the outcome groups only for the elective neurosurgical patients. Age, gender, heart rate, Glasgow Coma Scale scores, and tumor location, size, and malignancy were not related to outcome in the elective neurosurgery group. However, within the trauma group, low Glasgow Coma Scale scores were significantly related to poor outcome. CONCLUSIONS: Cardiac vagal tone may offer important predictive value by alerting the physician to the functional consequence of head injury. Information relating to autonomic nervous system functioning, such as the vagal tone index used in this study, may provide additional information that will complement the computed tomography scan results. This study demonstrates that the vagal tone index is a predictive factor that may be efficiently extracted from the heart rate pattern routinely monitored in ICUs.
OBJECTIVE: To evaluate the relationship between presurgical levels of cardiac vagal tone and outcome in neurosurgical patients. DESIGN: Prospective series. SETTING: Respiratory ICU in a university hospital. PATIENTS: Fifty-one adults admitted to the respiratory ICU between 1982 and 1985. Forty-two patients were scheduled for elective neurosurgery, and nine patients suffered from head trauma. INTERVENTIONS: Ten minutes of electrocardiographic (EKG) data were recorded before medical intervention. Neurosurgical patients scheduled for surgery had EKG data recorded 24 hrs before their operation. Traumapatients had EKG data recorded immediately after arrival in the respiratory ICU. MEASUREMENTS AND MAIN RESULTS: Cardiac vagal tone was evaluated using a vagal tone index, quantified from the EKG. Cardiac vagal tone monitored before surgical intervention significantly distinguished between the outcome groups only for the elective neurosurgical patients. Age, gender, heart rate, Glasgow Coma Scale scores, and tumor location, size, and malignancy were not related to outcome in the elective neurosurgery group. However, within the trauma group, low Glasgow Coma Scale scores were significantly related to poor outcome. CONCLUSIONS: Cardiac vagal tone may offer important predictive value by alerting the physician to the functional consequence of head injury. Information relating to autonomic nervous system functioning, such as the vagal tone index used in this study, may provide additional information that will complement the computed tomography scan results. This study demonstrates that the vagal tone index is a predictive factor that may be efficiently extracted from the heart rate pattern routinely monitored in ICUs.
Authors: John B Williamson; Greg Lewis; Angela J Grippo; Damon Lamb; Emily Harden; Mika Handleman; Jocelyn Lebow; C Sue Carter; Stephen W Porges Journal: Auton Neurosci Date: 2010-05-07 Impact factor: 3.145