Literature DB >> 16179517

Early effects of modulating nuclear factor-kappaB activation on traumatic spinal cord injury in rats.

Octavio Jiménez-Garza1, Javier Camacho, Antonio Ibarra, Angelina Martínez, Gabriel Guízar-Sahagún.   

Abstract

Genes regulated by NF-kappaB play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-kappaB, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats post-treated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-kappaB inhibition in acute SCI.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16179517     DOI： 10.1196/annals.1344.012

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  5 in total

1.  Disruption of Nrf2 enhances the upregulation of nuclear factor-kappaB activity, tumor necrosis factor-α, and matrix metalloproteinase-9 after spinal cord injury in mice.

Authors:  Lei Mao; Handong Wang; Liang Qiao; Xiaoliang Wang
Journal:  Mediators Inflamm       Date:  2010-08-24       Impact factor: 4.711

2.  MicroRNA-23b attenuates the H2O2-induced injury of microglial cells via TAB3/NF-κB signaling pathway.

Authors:  Xin Zhou; Jiajun Chen; Hongjun Zhang; Xiao Chen; Gaohai Shao
Journal:  Int J Clin Exp Pathol       Date:  2018-12-01

3.  Apolipoprotein E Deficiency Exacerbates Spinal Cord Injury in Mice: Inflammatory Response and Oxidative Stress Mediated by NF-κB Signaling Pathway.

Authors:  Xuan Yang; Shurui Chen; Zhenya Shao; Yuanlong Li; He Wu; Xian Li; Liang Mao; Zipeng Zhou; Liangjie Bai; Xifan Mei; Chang Liu
Journal:  Front Cell Neurosci       Date:  2018-05-23       Impact factor: 5.505

Review 4.  Role of nuclear factor kappa B in central nervous system regeneration.

Authors:  Christian Engelmann; Falk Weih; Ronny Haenold
Journal:  Neural Regen Res       Date:  2014-04-01       Impact factor: 5.135

5.  MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-κB pathway.

Authors:  Guang Wan; Yongbo An; Jingang Tao; Yanli Wang; Qinglan Zhou; Rongli Yang; Qiudong Liang
Journal:  Biosci Rep       Date:  2020-03-27       Impact factor: 3.840
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.