BACKGROUND: Up to 40% of newborn infants of women with type 1 diabetes have echocardiographic signs of cardiomyopathy. Increased plasma concentrations of B-type natriuretic peptide (BNP) and its precursor (proBNP) are markers of cardiac failure and hypoxia in adults. In this study, we investigated whether plasma concentrations of proBNP and/or BNP are increased in infants of women with type 1 diabetes. METHODS: Plasma BNP and proBNP were measured with RIAs. The proBNP assay measures both intact proBNP and NH(2)-terminal fragments derived from this precursor, whereas the BNP assay measures only BNP-32 and not proBNP. RESULTS: Infants of women with diabetes and hemoglobin A(1c) (Hb A(1c)) > or =6.2% before delivery had a higher median plasma proBNP concentration (31 pmol/L; interquartile range, 21-47 pmol/L; n = 16) than infants of healthy women [16 (9-32) pmol/L; n = 21; P = 0.01]. Infants of women with diabetes and Hb A(1c) <6.2% (n = 15) had intermediate values. The plasma BNP and proBNP concentrations were closely associated (r(2) = 0.80; P < 0.0001); within the group of infants of women with diabetes and Hb A(1c) > or =6.2%, both correlated with the degree of fetal stress during labor. CONCLUSIONS: Maternal diabetes and suboptimal metabolic control may affect the fetal heart and predominantly stimulate proBNP secretion in conjunction with perinatal stress.
BACKGROUND: Up to 40% of newborn infants of women with type 1 diabetes have echocardiographic signs of cardiomyopathy. Increased plasma concentrations of B-type natriuretic peptide (BNP) and its precursor (proBNP) are markers of cardiac failure and hypoxia in adults. In this study, we investigated whether plasma concentrations of proBNP and/or BNP are increased in infants of women with type 1 diabetes. METHODS: Plasma BNP and proBNP were measured with RIAs. The proBNP assay measures both intact proBNP and NH(2)-terminal fragments derived from this precursor, whereas the BNP assay measures only BNP-32 and not proBNP. RESULTS:Infants of women with diabetes and hemoglobin A(1c) (Hb A(1c)) > or =6.2% before delivery had a higher median plasma proBNP concentration (31 pmol/L; interquartile range, 21-47 pmol/L; n = 16) than infants of healthy women [16 (9-32) pmol/L; n = 21; P = 0.01]. Infants of women with diabetes and Hb A(1c) <6.2% (n = 15) had intermediate values. The plasma BNP and proBNP concentrations were closely associated (r(2) = 0.80; P < 0.0001); within the group of infants of women with diabetes and Hb A(1c) > or =6.2%, both correlated with the degree of fetal stress during labor. CONCLUSIONS:Maternal diabetes and suboptimal metabolic control may affect the fetal heart and predominantly stimulate proBNP secretion in conjunction with perinatal stress.
Authors: Mustafa Kurthan Mert; Mehmet Satar; Nazan Özbarlas; Akgün Yaman; Fatma Tuncay Özgünen; Hüseyin Selim Asker; Eren Kale Çekinmez; Tamer Tetiker Journal: Pediatr Cardiol Date: 2015-08-13 Impact factor: 1.655
Authors: Abigail Muñoz-Rodríguez; Jorge Alfonso Maciel-Ruiz; Ana María Salazar; Monserrat Sordo; Patricia Ostrosky-Wegman; Jorge H Limón-Pacheco; Andrés Eduardo Nepomuceno-Hernández; Rodrigo Ayala-Yáñez; María Eugenia Gonsebatt; Citlalli Osorio-Yáñez Journal: Int J Environ Res Public Health Date: 2021-06-18 Impact factor: 3.390