Literature DB >> 16178568

Enantioselective direct aldol-Tishchenko reaction: access to chiral stereopentads.

Kerstin Rohr1, Robert Herre, Rainer Mahrwald.   

Abstract

[reaction: see text] The aldol-Tishchenko reaction of aromatic aldehydes in the presence of titanium(IV) tertbutoxide and amino alcohols is described. When used with cinchona alkaloids, stereopentads were isolated for the first time with a high degree of diastereo- and enantioselectivity.

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Year:  2005        PMID: 16178568     DOI: 10.1021/ol0517675

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  2 in total

1.  Enantioselective Evans-Tishchenko reduction of β-hydroxyketone catalyzed by lithium binaphtholate.

Authors:  Tomonori Ichibakase; Masato Nakatsu; Makoto Nakajima
Journal:  Molecules       Date:  2011-06-17       Impact factor: 4.411

2.  Catalytic enantioselective intramolecular Tishchenko reaction of meso-dialdehyde: synthesis of (S)-cedarmycins.

Authors:  Nobuki Kishi; Yuki Adachi; Rui Jiang; Takahiro Doi; Da-Yang Zhou; Kaori Asano; Yasushi Obora; Takayoshi Suzuki; Hiroaki Sasai; Takeyuki Suzuki
Journal:  RSC Adv       Date:  2021-03-22       Impact factor: 3.361

  2 in total

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