| Literature DB >> 16178554 |
Samuel G Salamone1, Gregory B Dudley.
Abstract
[reaction: see text] Preparation of a cyclopentenone-fused pyrrolophane, which serves as a model for the tricyclic core of roseophilin (1), is described. The synthetic scheme features a palladium-catalyzed annulation and oxidative cleavage sequence to provide a macrocyclic ketoester (17). Modified Paal-Knorr pyrrole synthesis and Friedel-Crafts acylation complete the pyrrolophane model system (20).Entities:
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Year: 2005 PMID： 16178554 DOI： 10.1021/ol051730k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005