Literature DB >> 16178415

Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated from Achyranthes bidentata and Atractylodes japonica.

Sang-Bae Han1, Chang Woo Lee, Yeo Dae Yoon, Jong-Ho Lee, Jong Soon Kang, Ki Hoon Lee, Won Kee Yoon, Kiho Lee, Song-Kyu Park, Hwan Mook Kim.   

Abstract

An oriental herbal combination (BDX-1) was isolated from Achyranthes bidentata and Atractylodes japonica. We previously tested the clinical effectiveness of BDX-1 in rheumatoid arthritis (RA) patients and found that it has a beneficial therapeutic effect. Here, we provide experimental evidence for the effectiveness of BDX-1 on RA in murine models. The oral administration of BDX-1 was found to markedly inhibit collagen-induced arthritis, adjuvant-induced arthritis, and zymosan-induced inflammation. It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response. In addition, the biological activity of BDX-1 was found to be strongly increased by fermentation. Our results suggest that BDX-1 could be useful for the treatment of rheumatoid arthritis.

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Year:  2005        PMID： 16178415     DOI： 10.1007/bf02973875

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  9 in total

1.  Treatment with SiMiaoFang, an anti-arthritis chinese herbal formula, inhibits cartilage matrix degradation in osteoarthritis rat model.

Authors:  Ying Xu; Qian Liu; Zhen-Li Liu; Li Lim; Wei-Heng Chen; Na Lin
Journal:  Rejuvenation Res       Date:  2013-10       Impact factor: 4.663

2.  A cell-penetrating peptide suppresses inflammation by inhibiting NF-κB signaling.

Authors:  Yu Fu Wang; Xiang Xu; Xia Fan; Chun Zhang; Qiang Wei; Xi Wang; Wei Guo; Wei Xing; Jian Yu; Jing-Long Yan; Hua-Ping Liang
Journal:  Mol Ther       Date:  2011-05-10       Impact factor: 11.454

3.  Polysaccharides from the Chinese medicinal herb Achyranthes bidentata enhance anti-malarial immunity during Plasmodium yoelii 17XL infection in mice.

Authors:  Xiaotong Zhu; Yanyan Pan; Li Zheng; Liwang Cui; Yaming Cao
Journal:  Malar J       Date:  2012-02-20       Impact factor: 2.979

4.  Antioxidant Activities of Achyranthes japonica Nakai Extract and Its Application to the Pork Sausages.

Authors:  J H Park; S N Kang; D Shin; I C Hur; I S Kim; S K Jin
Journal:  Asian-Australas J Anim Sci       Date:  2013-02       Impact factor: 2.509

5.  Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling.

Authors:  Yini Jiang; Yanqiong Zhang; Weiheng Chen; Chunfang Liu; Xiaomin Li; Danni Sun; Zhenli Liu; Ying Xu; Xia Mao; Qiuyan Guo; Na Lin
Journal:  J Transl Med       Date:  2014-11-29       Impact factor: 5.531

6.  Effects of Achyranthes bidentata alcohol on proliferation capacity of osteoblasts and miRNA in Runx2.

Authors:  Shan Hua; Xuexue Zhang
Journal:  Exp Ther Med       Date:  2019-07-02       Impact factor: 2.447

7.  PIM1, CYP1B1, and HSPA2 Targeted by Quercetin Play Important Roles in Osteoarthritis Treatment by Achyranthes bidentata.

Authors:  Dujun Ma; Tian Yu; Liping Peng; Lixin Wang; Zhouwei Liao; Wenming Xu
Journal:  Evid Based Complement Alternat Med       Date:  2019-07-15       Impact factor: 2.629

8.  Protective effects and molecular mechanisms of Achyranthes bidentata polypeptide k on Schwann cells.

Authors:  Meiyuan Li; Ye Zhu; Leili Tang; Hua Xu; Jingfei Zhong; Wenqiang Peng; Ying Yuan; Xiaosong Gu; Hongkui Wang
Journal:  Ann Transl Med       Date:  2021-03

9.  Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products.

Authors:  Xuan Xia; Brian H May; Anthony Lin Zhang; Xinfeng Guo; Chuanjian Lu; Charlie C Xue; Qingchun Huang
Journal:  Evid Based Complement Alternat Med       Date:  2020-04-28       Impact factor: 2.629
  9 in total

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