Literature DB >> 16177826

Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression.

Magali Savignac1, Belen Pintado, Alfonso Gutierrez-Adan, Malgorzata Palczewska, Britt Mellström, Jose R Naranjo.   

Abstract

Downstream Regulatory Element Antagonist Modulator (DREAM) is a Ca2+-dependent transcriptional repressor expressed in the brain, thyroid gland and thymus. Here, we analyzed the function of DREAM and the related protein KChIP-2 in the immune system using transgenic (tg) mice expressing a cross-dominant active mutant (EFmDREAM) for DREAM and KChIPs Ca2+-dependent transcriptional derepression. EFmDREAM tg mice showed reduced T-cell proliferation. Tg T cells exhibited decreased interleukin (IL)-2, -4 and interferon (IFN)gamma production after polyclonal activation and following antigen-specific response. Chromatin immunoprecipitation and transfection assays showed that DREAM binds to and represses transcription from these cytokine promoters. Importantly, specific transient knockdown of DREAM or KChIP-2 induced basal expression of IL-2 and IFNgamma in wild-type splenocytes. These data propose DREAM and KChIP-2 as Ca2+-dependent repressors of the immune response.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16177826      PMCID： PMC1276700          DOI： 10.1038/sj.emboj.7600810

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  43 in total

Review 1.  K+ channels as targets for specific immunomodulation.

Authors:  K George Chandy; Heike Wulff; Christine Beeton; Michael Pennington; George A Gutman; Michael D Cahalan
Journal:  Trends Pharmacol Sci       Date:  2004-05       Impact factor: 14.819

Review 2.  Lymphocyte responses and cytokines.

Authors:  W E Paul; R A Seder
Journal:  Cell       Date:  1994-01-28       Impact factor: 41.582

3.  Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells.

Authors:  D Tzachanis; G J Freeman; N Hirano; A A van Puijenbroek; M W Delfs; A Berezovskaya; L M Nadler; V A Boussiotis
Journal:  Nat Immunol       Date:  2001-12       Impact factor: 25.606

4.  Subcellular calcium transients visualized by confocal microscopy in a voltage-clamped vertebrate neuron.

Authors:  A Hernández-Cruz; F Sala; P R Adams
Journal:  Science       Date:  1990-02-16       Impact factor: 47.728

5.  Activation of the interleukin-4 gene is controlled by the unique calcineurin-dependent transcriptional factor NF(P).

Authors:  M Kubo; R L Kincaid; J T Ransom
Journal:  J Biol Chem       Date:  1994-07-29       Impact factor: 5.157

6.  Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

Authors:  A Zweifach; R S Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

7.  Identification of a calcium-inducible, cyclosporine sensitive element in the IFN-gamma promoter that is a potential NFAT binding site.

Authors:  P M Campbell; J Pimm; V Ramassar; P F Halloran
Journal:  Transplantation       Date:  1996-03-27       Impact factor: 4.939

8.  Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Authors:  T R Mosmann; H Cherwinski; M W Bond; M A Giedlin; R L Coffman
Journal:  J Immunol       Date:  1986-04-01       Impact factor: 5.422

9.  Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation.

Authors:  N A Clipstone; G R Crabtree
Journal:  Nature       Date:  1992-06-25       Impact factor: 49.962

10.  Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression.

Authors:  Marcos Rivas; Britt Mellström; José R Naranjo; Pilar Santisteban
Journal:  J Biol Chem       Date:  2004-06-04       Impact factor: 5.157
View more
  37 in total

1.  The calcium channel alpha2/delta1 subunit is involved in extracellular signalling.

Authors:  Kelly García; Thomas Nabhani; Jesús García
Journal:  J Physiol       Date:  2007-12-06       Impact factor: 5.182

2.  Modulation of human Kv4.3/KChIP2 channel inactivation kinetics by cytoplasmic Ca2.

Authors:  Christiane Groen; Robert Bähring
Journal:  Pflugers Arch       Date:  2017-07-22       Impact factor: 3.657

3.  Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.

Authors:  José R Naranjo; Hongyu Zhang; Diego Villar; Paz González; Xose M Dopazo; Javier Morón-Oset; Elena Higueras; Juan C Oliveros; María D Arrabal; Angela Prieto; Pilar Cercós; Teresa González; Alicia De la Cruz; Juan Casado-Vela; Alberto Rábano; Carmen Valenzuela; Marta Gutierrez-Rodriguez; Jia-Yi Li; Britt Mellström
Journal:  J Clin Invest       Date:  2016-01-11       Impact factor: 14.808

4.  Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation.

Authors:  Jarkko J Ronkainen; Sandra L Hänninen; Topi Korhonen; Jussi T Koivumäki; Reka Skoumal; Sini Rautio; Veli-Pekka Ronkainen; Pasi Tavi
Journal:  J Physiol       Date:  2011-03-28       Impact factor: 5.182

5.  Calcium influx and DREAM protein are required for GnRH gene expression pulse activity.

Authors:  Gilles M Leclerc; Fredric R Boockfor
Journal:  Mol Cell Endocrinol       Date:  2006-12-27       Impact factor: 4.102

Review 6.  Neuronal Ca(2+) dyshomeostasis in Huntington disease.

Authors:  Marta Giacomello; Juan C Oliveros; Jose R Naranjo; Ernesto Carafoli
Journal:  Prion       Date:  2013-01-01       Impact factor: 3.931

7.  The DREAM protein is associated with thyroid enlargement and nodular development.

Authors:  Marcos Rivas; Britt Mellström; Begoña Torres; Gaetano Cali; Alfonso M Ferrara; Daniela Terracciano; Mariastella Zannini; Gabriella Morreale de Escobar; Jose R Naranjo
Journal:  Mol Endocrinol       Date:  2009-03-19

8.  DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory.

Authors:  Long-Jun Wu; Britt Mellström; Hansen Wang; Ming Ren; Sofia Domingo; Susan S Kim; Xiang-Yao Li; Tao Chen; Jose R Naranjo; Min Zhuo
Journal:  Mol Brain       Date:  2010-01-21       Impact factor: 4.041

9.  Selected microRNAs define cell fate determination of murine central memory CD8 T cells.

Authors:  Gonzalo Almanza; Antonio Fernandez; Stefano Volinia; Xochitl Cortez-Gonzalez; Carlo M Croce; Maurizio Zanetti
Journal:  PLoS One       Date:  2010-06-22       Impact factor: 3.240

10.  DREAM controls the on/off switch of specific activity-dependent transcription pathways.

Authors:  Britt Mellström; Ignasi Sahún; Ana Ruiz-Nuño; Patricia Murtra; Rosa Gomez-Villafuertes; Magali Savignac; Juan C Oliveros; Paz Gonzalez; Asta Kastanauskaite; Shira Knafo; Min Zhuo; Alejandro Higuera-Matas; Michael L Errington; Rafael Maldonado; Javier DeFelipe; John G R Jefferys; Tim V P Bliss; Mara Dierssen; Jose R Naranjo
Journal:  Mol Cell Biol       Date:  2013-12-23       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.