| Literature DB >> 16177791 |
Chad Nusbaum1, Michael C Zody, Mark L Borowsky, Michael Kamal, Chinnappa D Kodira, Todd D Taylor, Charles A Whittaker, Jean L Chang, Christina A Cuomo, Ken Dewar, Michael G FitzGerald, Xiaoping Yang, Amr Abouelleil, Nicole R Allen, Scott Anderson, Toby Bloom, Boris Bugalter, Jonathan Butler, April Cook, David DeCaprio, Reinhard Engels, Manuel Garber, Andreas Gnirke, Nabil Hafez, Jennifer L Hall, Catherine Hosage Norman, Takehiko Itoh, David B Jaffe, Yoko Kuroki, Jessica Lehoczky, Annie Lui, Pendexter Macdonald, Evan Mauceli, Tarjei S Mikkelsen, Jerome W Naylor, Robert Nicol, Cindy Nguyen, Hideki Noguchi, Sinéad B O'Leary, Keith O'Neill, Bruno Piqani, Cherylyn L Smith, Jessica A Talamas, Kerri Topham, Yasushi Totoki, Atsushi Toyoda, Hester M Wain, Sarah K Young, Qiandong Zeng, Andrew R Zimmer, Asao Fujiyama, Masahira Hattori, Bruce W Birren, Yoshiyuki Sakaki, Eric S Lander.
Abstract
Chromosome 18 appears to have the lowest gene density of any human chromosome and is one of only three chromosomes for which trisomic individuals survive to term. There are also a number of genetic disorders stemming from chromosome 18 trisomy and aneuploidy. Here we report the finished sequence and gene annotation of human chromosome 18, which will allow a better understanding of the normal and disease biology of this chromosome. Despite the low density of protein-coding genes on chromosome 18, we find that the proportion of non-protein-coding sequences evolutionarily conserved among mammals is close to the genome-wide average. Extending this analysis to the entire human genome, we find that the density of conserved non-protein-coding sequences is largely uncorrelated with gene density. This has important implications for the nature and roles of non-protein-coding sequence elements.Entities:
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Year: 2005 PMID： 16177791 DOI： 10.1038/nature03983
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962