Literature DB >> 16177385

Digalactoside expression in the lipopolysaccharide of Haemophilus influenzae and its role in intravascular survival.

Ruth Griffin1, Chris D Bayliss, Mark A Herbert, Andrew D Cox, Katherine Makepeace, James C Richards, Derek W Hood, E Richard Moxon.   

Abstract

Digalactoside (galalpha-1-4 galbeta) structures of the lipopolysaccharide (LPS) of Haemophilus influenzae are implicated in virulence. A confounding factor is that tetranucleotide repeats within the lic2A, lgtC, and lex2 genes mediate phase-variable expression of the digalactosides. By deleting these repeats, we constructed recombinant strains of RM153 constitutively expressing either one or two LPS digalactosides. Expression of two digalactosides, rather than one, was associated with increased virulence of H. influenzae in vivo.

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Year:  2005        PMID： 16177385      PMCID： PMC1230920          DOI： 10.1128/IAI.73.10.7022-7026.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  24 in total

1.  The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae affects binding and sensitivity to C-reactive protein-mediated killing.

Authors:  E Lysenko; J C Richards; A D Cox; A Stewart; A Martin; M Kapoor; J N Weiser
Journal:  Mol Microbiol       Date:  2000-01       Impact factor: 3.501

2.  The length of a tetranucleotide repeat tract in Haemophilus influenzae determines the phase variation rate of a gene with homology to type III DNA methyltransferases.

Authors:  X De Bolle; C D Bayliss; D Field; T van de Ven; N J Saunders; D W Hood; E R Moxon
Journal:  Mol Microbiol       Date:  2000-01       Impact factor: 3.501

3.  Structure of the variable and conserved lipopolysaccharide oligosaccharide epitopes expressed by Haemophilus influenzae serotype b strain Eagan.

Authors:  H Masoud; E R Moxon; A Martin; D Krajcarski; J C Richards
Journal:  Biochemistry       Date:  1997-02-25       Impact factor: 3.162

4.  DNA repeats identify novel virulence genes in Haemophilus influenzae.

Authors:  D W Hood; M E Deadman; M P Jennings; M Bisercic; R D Fleischmann; J C Venter; E R Moxon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205

5.  Tandem repeats of the tetramer 5'-CAAT-3' present in lic2A are required for phase variation but not lipopolysaccharide biosynthesis in Haemophilus influenzae.

Authors:  N J High; M P Jennings; E R Moxon
Journal:  Mol Microbiol       Date:  1996-04       Impact factor: 3.501

6.  Phase variation of Haemophilus influenzae lipopolysaccharide: characterization of lipopolysaccharide from individual colonies.

Authors:  R J Roche; N J High; E R Moxon
Journal:  FEMS Microbiol Lett       Date:  1994-07-15       Impact factor: 2.742

7.  Elucidation of the monoclonal antibody 5G8-reactive, virulence-associated lipopolysaccharide epitope of Haemophilus influenzae and its role in bacterial resistance to complement-mediated killing.

Authors:  Ruth Griffin; Andrew D Cox; Katherine Makepeace; James C Richards; E Richard Moxon; Derek W Hood
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

8.  Use of the complete genome sequence information of Haemophilus influenzae strain Rd to investigate lipopolysaccharide biosynthesis.

Authors:  D W Hood; M E Deadman; T Allen; H Masoud; A Martin; J R Brisson; R Fleischmann; J C Venter; J C Richards; E R Moxon
Journal:  Mol Microbiol       Date:  1996-12       Impact factor: 3.501

9.  Phenotypic variation in Haemophilus influenzae: the interrelationship of colony opacity, capsule and lipopolysaccharide.

Authors:  R J Roche; E R Moxon
Journal:  Microb Pathog       Date:  1995-02       Impact factor: 3.738

10.  The gal locus from Haemophilus influenzae: cloning, sequencing and the use of gal mutants to study lipopolysaccharide.

Authors:  D J Maskell; M J Szabo; M E Deadman; E R Moxon
Journal:  Mol Microbiol       Date:  1992-10       Impact factor: 3.501
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  9 in total

1.  Role of lgtC in resistance of nontypeable Haemophilus influenzae strain R2866 to human serum.

Authors:  Alice L Erwin; Simon Allen; Derek K Ho; Paul J Bonthuis; Paul J Bonthius; Justin Jarisch; Kevin L Nelson; David L Tsao; William C T Unrath; Michael E Watson; Bradford W Gibson; Michael A Apicella; Arnold L Smith
Journal:  Infect Immun       Date:  2006-09-11       Impact factor: 3.441

2.  Haemophilus parainfluenzae has a limited core lipopolysaccharide repertoire with no phase variation.

Authors:  Rosanna E B Young; Derek W Hood
Journal:  Glycoconj J       Date:  2012-10-24       Impact factor: 2.916

3.  Lex2B, a phase-variable glycosyltransferase, adds either a glucose or a galactose to Haemophilus influenzae lipopolysaccharide.

Authors:  M E Deadman; P Hermant; M Engskog; K Makepeace; E R Moxon; E K H Schweda; D W Hood
Journal:  Infect Immun       Date:  2009-03-16       Impact factor: 3.441

4.  The periplasmic disulfide oxidoreductase DsbA contributes to Haemophilus influenzae pathogenesis.

Authors:  Charles V Rosadini; Sandy M S Wong; Brian J Akerley
Journal:  Infect Immun       Date:  2008-01-22       Impact factor: 3.441

5.  Relative contributions of lipooligosaccharide inner and outer core modifications to nontypeable Haemophilus influenzae pathogenesis.

Authors:  Pau Morey; Cristina Viadas; Begoña Euba; Derek W Hood; Montserrat Barberán; Carmen Gil; María Jesús Grilló; José Antonio Bengoechea; Junkal Garmendia
Journal:  Infect Immun       Date:  2013-08-26       Impact factor: 3.441

6.  Outer membrane protein P5 is required for resistance of nontypeable Haemophilus influenzae to both the classical and alternative complement pathways.

Authors:  Charles V Rosadini; Sanjay Ram; Brian J Akerley
Journal:  Infect Immun       Date:  2013-11-25       Impact factor: 3.441

7.  Evasion of killing by human antibody and complement through multiple variations in the surface oligosaccharide of Haemophilus influenzae.

Authors:  Sarah E Clark; Kara R Eichelberger; Jeffrey N Weiser
Journal:  Mol Microbiol       Date:  2013-04-12       Impact factor: 3.501

8.  Identification of the functional initiation codons of a phase-variable gene of Haemophilus influenzae, lic2A, with the potential for differential expression.

Authors:  Kevin Dixon; Christopher D Bayliss; Katherine Makepeace; E Richard Moxon; Derek W Hood
Journal:  J Bacteriol       Date:  2006-11-10       Impact factor: 3.490

9.  Two Glycosyltransferase Genes of Haemophilus parasuis SC096 Implicated in Lipooligosaccharide Biosynthesis, Serum Resistance, Adherence, and Invasion.

Authors:  Qi Zhou; Saixiang Feng; Jianmin Zhang; Aiqing Jia; Kaijie Yang; Kaixiang Xing; Ming Liao; Huiying Fan
Journal:  Front Cell Infect Microbiol       Date:  2016-09-12       Impact factor: 5.293
  9 in total

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