| Literature DB >> 16176875 |
Michael J Fuertes1, Jaskiran Kaur, Prasant Deb, Barry S Cooperman, Amos B Smith.
Abstract
Inhibitors of mammalian ribonucleotide reductase possessing a novel octahydropyranopyrrole scaffold based on a cyclic heptapeptide inhibitor have been designed, synthesized, and evaluated. Structure-function studies reveal that the bicyclic scaffold is indeed necessary to maintain inhibitory activity.Entities:
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Year: 2005 PMID： 16176875 DOI： 10.1016/j.bmcl.2005.08.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823