Houyu Zhao1, Qianmei Chen, Jie Ren. 1. Department of Otolaryngology, The Affiliated Hospital of Guiyang Medical College, Guiyang, 550004, China.
Abstract
OBJECTIVE: To investigate the relationship between the local recurrence and the five years survival rate and the expression of Survivin in surgical margins of laryngeal squamous cell carcinoma. METHOD: Immunohistochemical technique (S-P) and image analysis were used to detect the expression of Survivin in the pathological negative margin specimen and primary site of cancer of 54 patients. RESULT: (1) Expression of Survivin was detected in 66. 7% (36/54) in laryngeal carcinoma, 40.7% (22/54) in surgical margins and negative in normal mucous membrane of palatoglossal pillar. A significant difference was observed for positive index(PI) in three groups (P < 0.01). (2) PI of Survival in surgical margins of patients with the local recurrence was higher than those with no local recurrence (P < 0.01). (3) The 5-year survival rate of patients with Survivin positive margin was lower than those with negative margin (29.3% vs 58.5%, P < 0.01). CONCLUSION: The expression of Survivin in surgical margins may predict the possibility of local recurrence and poor prognosis in a certain extent for patients with laryngeal carcinoma, which may guide the treatment after surgery.
OBJECTIVE: To investigate the relationship between the local recurrence and the five years survival rate and the expression of Survivin in surgical margins of laryngeal squamous cell carcinoma. METHOD: Immunohistochemical technique (S-P) and image analysis were used to detect the expression of Survivin in the pathological negative margin specimen and primary site of cancer of 54 patients. RESULT: (1) Expression of Survivin was detected in 66. 7% (36/54) in laryngeal carcinoma, 40.7% (22/54) in surgical margins and negative in normal mucous membrane of palatoglossal pillar. A significant difference was observed for positive index(PI) in three groups (P < 0.01). (2) PI of Survival in surgical margins of patients with the local recurrence was higher than those with no local recurrence (P < 0.01). (3) The 5-year survival rate of patients with Survivin positive margin was lower than those with negative margin (29.3% vs 58.5%, P < 0.01). CONCLUSION: The expression of Survivin in surgical margins may predict the possibility of local recurrence and poor prognosis in a certain extent for patients with laryngeal carcinoma, which may guide the treatment after surgery.