John W Finnie1. 1. Veterinary Services Division, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia. john.finnie@imvs.sa.gov.au
Abstract
AIMS: To study the effect of acute exposure to global system for mobile communication radiofrequency fields on immediate early gene, c-fos, expression in the brain. METHODS: Using a purpose-designed exposure system at 900 MHz, mice were given a single, far-field, whole body exposure for 60 minutes at a specific absorption rate of 4 W/kg. Control mice were sham-exposed or freely mobile in a cage without further restraint. c-fos protein expression was detected immunohistochemically in perfusion-fixed brains. RESULTS: Activation of c-fos in exposed and sham-exposed brains was comparable, but was greatly increased compared with freely moving controls. CONCLUSION: These results suggest that the majority of the acute genomic response detected by c-fos expression was due to immobilisation rather than irradiation.
AIMS: To study the effect of acute exposure to global system for mobile communication radiofrequency fields on immediate early gene, c-fos, expression in the brain. METHODS: Using a purpose-designed exposure system at 900 MHz, mice were given a single, far-field, whole body exposure for 60 minutes at a specific absorption rate of 4 W/kg. Control mice were sham-exposed or freely mobile in a cage without further restraint. c-fos protein expression was detected immunohistochemically in perfusion-fixed brains. RESULTS: Activation of c-fos in exposed and sham-exposed brains was comparable, but was greatly increased compared with freely moving controls. CONCLUSION: These results suggest that the majority of the acute genomic response detected by c-fos expression was due to immobilisation rather than irradiation.
Authors: T Jorge-Mora; M J Misa-Agustiño; J A Rodríguez-González; F J Jorge-Barreiro; F J Ares-Pena; E López-Martín Journal: Neurochem Res Date: 2011-08-05 Impact factor: 3.996