PURPOSE: This study was done to evaluate the hemodynamic effects of a pumpless implantable extracorporeal membrane oxygenation (ECMO) circuit between the right ventricle (RV) and left atrium (LA) in a chronic canine model with an RV pressure overload. METHOD: We created a model of right-sided heart failure by pulmonary artery banding in ten dogs for a duration of more than 3 months. After demonstrating that the RV pressure increased, a bypass circuit was created between the RV and LA with an in-line oxygenator. Both the hemodynamics and gas exchange were measured. RESULTS: The effects of a pulmonary bypass in nine dogs were studied. Approximately half of the RV output was passively shunted through the bypass circuit, and a marked reduction in the RV pressure and recovery from right heart failure were observed. After a complete ligation of the main pulmonary artery, five of the nine dogs survived more than 6 h. The RV pressure did not change significantly, but the cardiac output and blood pressure gradually decreased. The blood gas state was sufficiently maintained throughout the experiment. CONCLUSION: The present study indicates the hemodynamic benefit of a partial pumpless ECMO system in dogs with chronically pressure-overloaded right heart failure; however, the experimental preparation of the total pumpless ECMO circuit proved to be unstable.
PURPOSE: This study was done to evaluate the hemodynamic effects of a pumpless implantable extracorporeal membrane oxygenation (ECMO) circuit between the right ventricle (RV) and left atrium (LA) in a chronic canine model with an RV pressure overload. METHOD: We created a model of right-sided heart failure by pulmonary artery banding in ten dogs for a duration of more than 3 months. After demonstrating that the RV pressure increased, a bypass circuit was created between the RV and LA with an in-line oxygenator. Both the hemodynamics and gas exchange were measured. RESULTS: The effects of a pulmonary bypass in nine dogs were studied. Approximately half of the RV output was passively shunted through the bypass circuit, and a marked reduction in the RV pressure and recovery from right heart failure were observed. After a complete ligation of the main pulmonary artery, five of the nine dogs survived more than 6 h. The RV pressure did not change significantly, but the cardiac output and blood pressure gradually decreased. The blood gas state was sufficiently maintained throughout the experiment. CONCLUSION: The present study indicates the hemodynamic benefit of a partial pumpless ECMO system in dogs with chronically pressure-overloaded right heart failure; however, the experimental preparation of the total pumpless ECMO circuit proved to be unstable.
Authors: Scott D Lick; Donald J Deyo; Dongfang Wang; Sarah A Witt; Scott K Alpard; Donald D Harper; Joseph B Zwischenberger Journal: J Invest Surg Date: 2003 May-Jun Impact factor: 2.533
Authors: Jonathan W Haft; Joseph L Bull; Rebecca Rose; Jeffrey Katsra; James B Grotberg; Robert H Bartlett; Ronald B Hirschl Journal: ASAIO J Date: 2003 Jan-Feb Impact factor: 2.872
Authors: M K Pasque; E P Trulock; J D Cooper; A N Triantafillou; C B Huddleston; M Rosenbloom; S Sundaresan; J L Cox; G A Patterson Journal: Circulation Date: 1995-10-15 Impact factor: 29.690
Authors: H Yasui; H Kado; K Yonenaga; M Hisahara; H Ando; H Iwao; S Fukuda; Y Mizoguchi; H Sunagawa Journal: J Thorac Cardiovasc Surg Date: 1989-10 Impact factor: 5.209