INTRODUCTION: Diabetic ketoacidosis (DKA) continues to be a medical emergency, in part because of a rare and devastating complication associated with its treatment, cerebral edema. In children, cerebral edema is the principal cause of mortality, but clinically significant cerebral edema in adults is rare. METHODS AND RESULTS: We report the case of a 27-year-old male (not previously known to be diabetic) who presented with a first episode of DKA complicated by the development of fatal cerebral edema despite medical treatment. CONCLUSION: The pathophysiological mechanisms for cerebral edema associated with DKA occurring in children and adults are believed to be similar and are discussed in this report. However, patients who develop cerebral edema may deteriorate rapidly, and experience with successful treatment has been limited.
INTRODUCTION:Diabetic ketoacidosis (DKA) continues to be a medical emergency, in part because of a rare and devastating complication associated with its treatment, cerebral edema. In children, cerebral edema is the principal cause of mortality, but clinically significant cerebral edema in adults is rare. METHODS AND RESULTS: We report the case of a 27-year-old male (not previously known to be diabetic) who presented with a first episode of DKA complicated by the development of fatal cerebral edema despite medical treatment. CONCLUSION: The pathophysiological mechanisms for cerebral edema associated with DKA occurring in children and adults are believed to be similar and are discussed in this report. However, patients who develop cerebral edema may deteriorate rapidly, and experience with successful treatment has been limited.
Authors: Mark W J Strachan; Graham R Nimmo; Kathryn Noyes; David Simpson; Christopher J H Kelnar Journal: Diabetes Metab Res Rev Date: 2003 May-Jun Impact factor: 4.876
Authors: S P Laing; A J Swerdlow; S D Slater; J L Botha; A C Burden; N R Waugh; A W Smith; R D Hill; P J Bingley; C C Patterson; Z Qiao; H Keen Journal: Diabet Med Date: 1999-06 Impact factor: 4.359
Authors: W H Hoffman; C M Steinhart; T el Gammal; S Steele; A R Cuadrado; P K Morse Journal: AJNR Am J Neuroradiol Date: 1988 Jul-Aug Impact factor: 3.825
Authors: Eric Michael Liotta; Anna L Romanova; Bryan D Lizza; Laura J Rasmussen-Torvik; Minjee Kim; Brandon Francis; Rajbeer Singh Sangha; Timothy J Carroll; Daniel Ganger; Daniela P Ladner; Andrew M Naidech; James J Paparello; Shyam Prabhakaran; Farzaneh A Sorond; Matthew B Maas Journal: Crit Care Med Date: 2018-02 Impact factor: 7.598