Literature DB >> 16174871

A strategy for integrative computational physiology.

Peter Hunter1, Poul Nielsen.   

Abstract

Organ function (the heart beat for example) can only be understood through knowledge of molecular and cellular processes within the constraints of structure-function relations at the tissue level. A quantitative modeling framework that can deal with these multiscale issues is described here under the banner of the International Union of Physiological Sciences Physiome Project.

Mesh：

Year:  2005        PMID： 16174871     DOI： 10.1152/physiol.00022.2005

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  33 in total

1.  Mathematical challenges in integrative physiology.

Authors:  B S Brook; S L Waters
Journal:  J Math Biol       Date:  2008-06       Impact factor: 2.259

Review 2.  Evaluating the adaptive-filter model of the cerebellum.

Authors:  Paul Dean; John Porrill
Journal:  J Physiol       Date:  2011-04-18       Impact factor: 5.182

3.  Similar mitochondrial activation kinetics in wild-type and creatine kinase-deficient fast-twitch muscle indicate significant Pi control of respiration.

Authors:  Jeroen A L Jeneson; Frank ter Veld; Joep P J Schmitz; Ronald A Meyer; Peter A J Hilbers; Klaas Nicolay
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-03-30       Impact factor: 3.619

4.  Simulating microdosimetry in a virtual hepatic lobule.

Authors:  John Wambaugh; Imran Shah
Journal:  PLoS Comput Biol       Date:  2010-04-22       Impact factor: 4.475

Review 5.  Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo.

Authors:  Rita Guzun; Valdur Saks
Journal:  Int J Mol Sci       Date:  2010-03-08       Impact factor: 6.208

6.  An overview of the CellML API and its implementation.

Authors:  Andrew K Miller; Justin Marsh; Adam Reeve; Alan Garny; Randall Britten; Matt Halstead; Jonathan Cooper; David P Nickerson; Poul F Nielsen
Journal:  BMC Bioinformatics       Date:  2010-04-08       Impact factor: 3.169

7.  Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention.

Authors:  Yanhang Zhang; Victor H Barocas; Scott A Berceli; Colleen E Clancy; David M Eckmann; Marc Garbey; Ghassan S Kassab; Donna R Lochner; Andrew D McCulloch; Roger Tran-Son-Tay; Natalia A Trayanova
Journal:  Ann Biomed Eng       Date:  2016-05-02       Impact factor: 3.934

Review 8.  Philosophical basis and some historical aspects of systems biology: from Hegel to Noble - applications for bioenergetic research.

Authors:  Valdur Saks; Claire Monge; Rita Guzun
Journal:  Int J Mol Sci       Date:  2009-03-13       Impact factor: 5.923

9.  Metabolic compartmentation - a system level property of muscle cells: real problems of diffusion in living cells.

Authors:  Valdur Saks; Nathalie Beraud; Theo Wallimann
Journal:  Int J Mol Sci       Date:  2008-05-09       Impact factor: 6.208

10.  Strong inference for systems biology.

Authors:  Daniel A Beard; Martin J Kushmerick
Journal:  PLoS Comput Biol       Date:  2009-08-28       Impact factor: 4.475
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