Literature DB >> 16174490

Neuroendocrine-immune aspects of accelerated aging in rheumatoid arthritis.

Peter Härle1, Rainer H Straub.   

Abstract

The normal process of aging brings about changes in immune function, hormonal status, overall metabolism, and enhanced occurrence of neuropsychiatric disorders. These alterations are also evident at an accelerating pace in chronic inflammatory diseases. Treatment with immunosuppressive therapeutics is often not sufficiently effective. Treating neuroendocrine-immune alterations to regain homeostasis might enhance remission inducing and maintaining effects. This paper summarizes the phenomena related to normal aging and related to chronic inflammatory disease. Furthermore, a multimodal concept is being proposed to control more effectively chronic inflammatory disease on a neuroendocrine-immune basis.

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Year:  2005        PMID： 16174490     DOI： 10.1007/s11926-005-0027-6

Source DB:  PubMed          Journal:  Curr Rheumatol Rep        ISSN： 1523-3774            Impact factor:   4.592


  48 in total

1.  The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages.

Authors:  L E Miller; H P Jüsten; J Schölmerich; R H Straub
Journal:  FASEB J       Date:  2000-10       Impact factor: 5.191

Review 2.  The process of aging changes the interplay of the immune, endocrine and nervous systems.

Authors:  R H Straub; M Cutolo; B Zietz; J Schölmerich
Journal:  Mech Ageing Dev       Date:  2001-09-30       Impact factor: 5.432

3.  The autonomic nervous system and the immune system in juvenile rheumatoid arthritis.

Authors:  W Kuis; C de Jong-de Vos van Steenwijk; G Sinnema; A Kavelaars; B Prakken; P J Helders; C J Heijnen
Journal:  Brain Behav Immun       Date:  1996-12       Impact factor: 7.217

Review 4.  The endocrinology of aging.

Authors:  S W Lamberts; A W van den Beld; A J van der Lely
Journal:  Science       Date:  1997-10-17       Impact factor: 47.728

5.  Hyperhomocysteinemia in high-aged subjects: relation of B-vitamins, folic acid, renal function and the methylenetetrahydrofolate reductase mutation.

Authors:  W Herrmann; S Quast; M Ullrich; H Schultze; M Bodis; J Geisel
Journal:  Atherosclerosis       Date:  1999-05       Impact factor: 5.162

6.  Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency.

Authors:  P Ammann; R Rizzoli; J P Bonjour; S Bourrin; J M Meyer; P Vassalli; I Garcia
Journal:  J Clin Invest       Date:  1997-04-01       Impact factor: 14.808

Review 7.  Advanced protein glycosylation in diabetes and aging.

Authors:  M Brownlee
Journal:  Annu Rev Med       Date:  1995       Impact factor: 13.739

8.  Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression.

Authors:  D B Hales
Journal:  Endocrinology       Date:  1992-11       Impact factor: 4.736

9.  Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion.

Authors:  Rainer H Straub; Georg Pongratz; Jürgen Schölmerich; Frieder Kees; Thomas F Schaible; Christian Antoni; Joachim R Kalden; Hanns-Martin Lorenz
Journal:  Arthritis Rheum       Date:  2003-06

10.  Serum zinc and copper in patients with atherosclerosis and thromboangiitis obliterans.

Authors:  G Uza; R Vlaicu
Journal:  Biol Trace Elem Res       Date:  1989-06       Impact factor: 3.738
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  1 in total

Review 1.  Sympathetic modulation of immunity: relevance to disease.

Authors:  Denise L Bellinger; Brooke A Millar; Sam Perez; Jeff Carter; Carlo Wood; Srinivasan ThyagaRajan; Christine Molinaro; Cheri Lubahn; Dianne Lorton
Journal:  Cell Immunol       Date:  2008-03-04       Impact factor: 4.868
  1 in total

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