Literature DB >> 16173778

Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery.

Erwann Picquet1, Karine Le Ny, Pascal Delépine, Tristan Montier, Jean-Jacques Yaouanc, Dominique Cartier, Hervé des Abbayes, Claude Férec, Jean-Claude Clément.   

Abstract

Two new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and "lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs).

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16173778     DOI： 10.1021/bc050097k

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  7 in total

1.  Fluorescence study of lipid-based DNA carriers properties: influence of cationic lipid chemical structure.

Authors:  Laure Burel-Deschamps; Mathieu Mével; Damien Loizeau; Farouk Ayadi; Jean-Jacques Yaouanc; Jean-Claude Clément; Paul-Alain Jaffrès; Philippe Giamarchi
Journal:  J Fluoresc       Date:  2008-01-26       Impact factor: 2.217

Review 2.  Nature as a source of inspiration for cationic lipid synthesis.

Authors:  Romain Labas; Fanny Beilvert; Benoit Barteau; Stéphanie David; Raphaël Chèvre; Bruno Pitard
Journal:  Genetica       Date:  2009-09-11       Impact factor: 1.082

3.  Polypeptides with quaternary phosphonium side chains: synthesis, characterization, and cell-penetrating properties.

Authors:  Ziyuan Song; Nan Zheng; Xiaochu Ba; Lichen Yin; Rujing Zhang; Liang Ma; Jianjun Cheng
Journal:  Biomacromolecules       Date:  2014-03-17       Impact factor: 6.988

4.  Folate-equipped nanolipoplexes mediated efficient gene transfer into human epithelial cells.

Authors:  Emmanuel Mornet; Nathalie Carmoy; Céline Lainé; Loïc Lemiègre; Tony Le Gall; Isabelle Laurent; Remi Marianowski; Claude Férec; Pierre Lehn; Thierry Benvegnu; Tristan Montier
Journal:  Int J Mol Sci       Date:  2013-01-14       Impact factor: 5.923

Review 5.  Atherton-Todd reaction: mechanism, scope and applications.

Authors:  Stéphanie S Le Corre; Mathieu Berchel; Hélène Couthon-Gourvès; Jean-Pierre Haelters; Paul-Alain Jaffrès
Journal:  Beilstein J Org Chem       Date:  2014-05-21       Impact factor: 2.883

6.  Phosphonodithioester-Amine Coupling as a Key Reaction Step for the Design of Cationic Amphiphiles Used for Gene Delivery.

Authors:  Montassar Khalil; Alexis Hocquigny; Mathieu Berchel; Tristan Montier; Paul-Alain Jaffrès
Journal:  Molecules       Date:  2021-12-11       Impact factor: 4.411

7.  Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes.

Authors:  Tony Le Gall; Mathieu Berchel; Lee Davies; Angélique Mottais; Rosy Ghanem; Alain Fautrel; Deborah Gill; Steve Hyde; Pierre Lehn; Jean-Marie Lehn; Loïc Lemiègre; Thierry Benvegnu; Paul-Alain Jaffrès; Bruno Pitard; Tristan Montier
Journal:  Pharmaceutics       Date:  2021-12-23       Impact factor: 6.321
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.