Literature DB >> 16171994

A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents.

Anu Agarwal1, Kumkum Srivastava, S K Puri, S Sinha, Prem M S Chauhan.   

Abstract

A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activities. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2microg/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H(37)Ra, at a concentration of 12.5microg/mL.

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Year:  2005        PMID： 16171994     DOI： 10.1016/j.bmcl.2005.08.053

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Antituberculosis activity of the molecular libraries screening center network library.

Authors:  Joseph A Maddry; Subramaniam Ananthan; Robert C Goldman; Judith V Hobrath; Cecil D Kwong; Clinton Maddox; Lynn Rasmussen; Robert C Reynolds; John A Secrist; Melinda I Sosa; E Lucile White; Wei Zhang
Journal:  Tuberculosis (Edinb)       Date:  2009-09-26       Impact factor: 3.131

2.  4,5,8a-Triphenyl-perhydro-pyrimido[4,5-d]pyrimidine-2,7-dione monohydrate.

Authors:  Yulin Zhu; Wanhong Qiu; Fufen Yang; Guichan Li
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-29

3.  DFT, ADMET and Molecular Docking Investigations for the Antimicrobial Activity of 6,6'-Diamino-1,1',3,3'-tetramethyl-5,5'-(4-chlorobenzylidene)bis[pyrimidine-2,4(1H,3H)-dione].

Authors:  Nesreen T El-Shamy; Ahmed M Alkaoud; Rageh K Hussein; Moez A Ibrahim; Abdulrahman G Alhamzani; Mortaga M Abou-Krisha
Journal:  Molecules       Date:  2022-01-18       Impact factor: 4.411
  3 in total

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