Literature DB >> 16170253

Neurobehavioral effects of amantadine after pediatric traumatic brain injury: a preliminary report.

Sue R Beers1, Anna Skold, Clifton Edward Dixon, Philip David Adelson.   

Abstract

OBJECTIVE: To investigate the safety and efficacy of a dopamine agonist, amantadine hydrochloride (AMH), in the treatment of neurobehavioral sequelae of pediatric TBI. PROCEDURES: Age- and severity-matched traumatic brain injury groups, randomized to AMH (n = 17) or usual care (n = 10), completed behavior scales and neuropsychological tests. Effect sizes measured the treatment effect within subjects and between groups. Side effects were tracked over the 12-week study course.
RESULTS: Behavior improved in the AMH group, but only those 2 years or fewer postinjury showed a treatment effect on cognitive tests.
CONCLUSIONS: After traumatic brain injury, a 12-week course of AMH was safe and, according to parent report, improved behavior. AMH may have the potential to improve cognition in more recently injured children.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16170253     DOI： 10.1097/00001199-200509000-00006

Source DB:  PubMed          Journal:  J Head Trauma Rehabil        ISSN： 0885-9701            Impact factor:   2.710


  8 in total

Review 1.  Medical therapies for concussion.

Authors:  William P Meehan
Journal:  Clin Sports Med       Date:  2011-01       Impact factor: 2.182

2.  Acute brain injury and therapeutic hypothermia in the PICU: A rehabilitation perspective.

Authors:  Ericka L Fink; Sue R Beers; Mary Louise Russell; Michael J Bell
Journal:  J Pediatr Rehabil Med       Date:  2009

3.  Cocaine self-administration is increased after frontal traumatic brain injury and associated with neuroinflammation.

Authors:  Cole Vonder Haar; Jacqueline-Marie N Ferland; Sukhbir Kaur; Lara-Kirstie Riparip; Susanna Rosi; Catharine A Winstanley
Journal:  Eur J Neurosci       Date:  2018-10-10       Impact factor: 3.386

4.  The effects of anticholinergic medications on cognition in children: a systematic review and meta-analysis.

Authors:  Erica Ghezzi; Michelle Chan; Lisa M Kalisch Ellett; Tyler J Ross; Kathryn Richardson; Jun Ni Ho; Dayna Copley; Claire Steele; Hannah A D Keage
Journal:  Sci Rep       Date:  2021-01-08       Impact factor: 4.379

5.  A Case for Mental and Physical Rest in Youth Sports Concussion: It's Never too Late.

Authors:  Rosemarie Scolaro Moser; Philip Schatz
Journal:  Front Neurol       Date:  2012-12-11       Impact factor: 4.003

Review 6.  Stimulant Therapy Utilization for Neurocognitive Deficits in Mild Traumatic Brain Injury.

Authors:  Eric E Coris; Byron Moran; Kevin Sneed; Gianluca Del Rossi; Bradford Bindas; Shaan Mehta; Dusty Narducci
Journal:  Sports Health       Date:  2021-07-22       Impact factor: 4.355

7.  Prescribing Patterns of Amantadine During Pediatric Inpatient Rehabilitation After Traumatic Brain Injury: A Multicentered Retrospective Review From the Pediatric Brain Injury Consortium.

Authors:  Matthew J McLaughlin; Eric Caliendo; Ryan Lowder; William D Watson; Brad Kurowski; Katherine T Baum; Laura S Blackwell; Christine H Koterba; Kristen R Hoskinson; Sarah J Tlustos; Kanecia O Zimmerman; Sudhin A Shah; Stacy J Suskauer
Journal:  J Head Trauma Rehabil       Date:  2021-07-26       Impact factor: 3.117

Review 8.  Amantadine: reappraisal of the timeless diamond-target updates and novel therapeutic potentials.

Authors:  Wojciech Danysz; Andrzej Dekundy; Astrid Scheschonka; Peter Riederer
Journal:  J Neural Transm (Vienna)       Date:  2021-02-23       Impact factor: 3.575
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.