Literature DB >> 16169535

Synthesis of a C3-symmetric (1-->6)-N-acetyl-beta-D-glucosamine octadecasaccharide using click chemistry.

Qi Chen1, Feng Yang, Yuguo Du.   

Abstract

A C3-symmetric (1-->6)-N-acetyl-beta-D-glucosamine octadecasaccharide was convergently synthesized on the basis of a copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of azide and alkyne. The target octadecasaccharide showed good antitumor activity against H22 in the preliminary mice tests.

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Year:  2005        PMID: 16169535     DOI: 10.1016/j.carres.2005.08.013

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN: 0008-6215            Impact factor:   2.104


  3 in total

1.  Antitumor activities of D-glucosamine and its derivatives.

Authors:  Li Zhang; Wan-shun Liu; Bao-qin Han; Yan-fei Peng; Dong-feng Wang
Journal:  J Zhejiang Univ Sci B       Date:  2006-08       Impact factor: 3.066

2.  Design and synthesis of multivalent neoglycoconjugates by click conjugations.

Authors:  Feiqing Ding; Li Ji; Ronny William; Hua Chai; Xue-Wei Liu
Journal:  Beilstein J Org Chem       Date:  2014-06-10       Impact factor: 2.883

3.  Synthesis of α-O- and α-S-glycosphingolipids related to Sphingomonous cell wall antigens using anomerisation.

Authors:  Wayne Pilgrim; Ciaran O'Reilly; Paul V Murphy
Journal:  Molecules       Date:  2013-09-12       Impact factor: 4.411

  3 in total

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