Literature DB >> 16169459

A new mouse model of pancreatic cancer: PTEN gets its Akt together.

Anirban Maitra1, Ralph H Hruban.   

Abstract

PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a negative regulator of the oncogenic PI3-K/Akt signaling pathway. Loss-of-function mutations of PTEN are seen in several human solid cancers. A murine model of conditional Pten inactivation in the pancreas is described that leads to acquisition of a profound metaplastic ductal phenotype accompanied by loss of differentiated acinar units. Evidence is presented for a centroacinar cell origin of the metaplastic "neoductules." These mice also develop invasive pancreatic adenocarcinomas at a low frequency, and provide a unique in vivo platform for exploring the role of PI3-K/Akt signaling in pancreatic neoplasia.

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Year:  2005        PMID： 16169459     DOI： 10.1016/j.ccr.2005.08.007

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  12 in total

1.  Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma.

Authors:  Ruben Plentz; Ji-Sun Park; Andrew D Rhim; Daniel Abravanel; Aram F Hezel; Sreenath V Sharma; Sushma Gurumurthy; Vikram Deshpande; Candia Kenific; Jeffrey Settleman; Pradip K Majumder; Ben Z Stanger; Nabeel Bardeesy
Journal:  Gastroenterology       Date:  2009-01-14       Impact factor: 22.682

Review 2.  Molecular biology of pancreatic cancer.

Authors:  Miroslav Zavoral; Petra Minarikova; Filip Zavada; Cyril Salek; Marek Minarik
Journal:  World J Gastroenterol       Date:  2011-06-28       Impact factor: 5.742

Review 3.  Histological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancer.

Authors:  J D Liao; N V Adsay; F Khannani; D Grignon; A Thakur; F H Sarkar
Journal:  Histol Histopathol       Date:  2007-06       Impact factor: 2.303

4.  Adenovirus mediated homozygous endometrial epithelial Pten deletion results in aggressive endometrial carcinoma.

Authors:  Ayesha Joshi; Lora Hedrick Ellenson
Journal:  Exp Cell Res       Date:  2011-03-21       Impact factor: 3.905

5.  Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer.

Authors:  Brian M Wolpin; Aram F Hezel; Thomas Abrams; Lawrence S Blaszkowsky; Jeffrey A Meyerhardt; Jennifer A Chan; Peter C Enzinger; Brittany Allen; Jeffrey W Clark; David P Ryan; Charles S Fuchs
Journal:  J Clin Oncol       Date:  2008-12-01       Impact factor: 44.544

6.  Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells.

Authors:  Daoyan Wei; Masahsi Kanai; Zhiliang Jia; Xiangdong Le; Keping Xie
Journal:  Cancer Res       Date:  2008-06-15       Impact factor: 12.701

7.  Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy.

Authors:  Ashiq Masood; Asfar S Azmi; Ramzi M Mohammad
Journal:  Cancers (Basel)       Date:  2011-06-01       Impact factor: 6.639

8.  Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic mice.

Authors:  Dezhong Joshua Liao; Yong Wang; Jiusheng Wu; Nazmi Volkan Adsay; David Grignon; Fayyaz Khanani; Fazlul H Sarkar
Journal:  J Carcinog       Date:  2006-07-05

9.  MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer.

Authors:  Marta Passadouro; Maria C Pedroso de Lima; Henrique Faneca
Journal:  Int J Nanomedicine       Date:  2014-07-03

10.  Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.

Authors:  Minzhao Huang; Su-Ni Tang; Ghanshyam Upadhyay; Justin L Marsh; Christopher P Jackman; Sharmila Shankar; Rakesh K Srivastava
Journal:  PLoS One       Date:  2014-04-02       Impact factor: 3.240
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