| Literature DB >> 16169234 |
Dang Ngoc Quang1, Toshihiro Hashimoto, Yuuki Arakawa, Chie Kohchi, Takashi Nishizawa, Gen-Ichiro Soma, Yoshinori Asakawa.
Abstract
Two new farnesyl phenols named grifolinones A and B, together with known grifolin and neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus caeruleoporus. Their structures were characterized by a combination of 2D NMR, MS, IR, and UV spectra. Grifolinone B was composed of two grifolin molecules, which were connected by a C-C bond. Grifolinones A and B, grifolin, and neogrifolin exhibited inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with IC50values of 23.4, 22.9, 29.0, and 23.3 microM, respectively.Entities:
Mesh：
Substances：
Year: 2005 PMID： 16169234 DOI： 10.1016/j.bmc.2005.08.005
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641