| Literature DB >> 16169214 |
Kazunori Yamamoto1, Naoki Watanabe, Hiroko Matsuda, Keiichiro Oohara, Tomoyuki Araya, Masaru Hashimoto, Kazuo Miyairi, Isao Okazaki, Minoru Saito, Tetsuya Shimizu, Hiroaki Kato, Toshikatsu Okuno.
Abstract
A sulfur-substituted analogue of trigalacturonic acid (3) was synthesized. The synthesis features the application of 3-cyano-3-(tert-butyldimethylsilyl)oxypropylthioether (CSP) as a novel protective group for thiols. This analogue was designed with the expectation that it would be a stable analogous substrate for endo-polygalacturonase isolated from Stereum purpureum based on computer modeling experiments. Surface plasmon resonance experiments revealed that 3 forms a stable complex with the target enzyme.Entities:
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Year: 2005 PMID： 16169214 DOI： 10.1016/j.bmcl.2005.08.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823