| Literature DB >> 16169207 |
Xinhui Tang1, Jing Gao, Yanping Wang, Yi-Mei Fan, Li-Zhi Xu, Xiao-Ning Zhao, Qiang Xu, Zhong Ming Qian.
Abstract
The protective effects of chloroform extracts of Terminalia catappa L. leaves (TCCE) on carbon tetrachloride (CCl4)-induced liver damage and the possible mechanisms involved in the protection were investigated in mice. We found that increases in the activity of serum aspartate aminotransferase and alanine aminotransferase and the level of liver lipid peroxidation (2.0-fold, 5.7-fold and 2.8-fold) induced by CCl4 were significantly inhibited by oral pretreatment with 20, 50 or 100 mg/kg of TCCE. Morphological observation further confirmed the hepatoprotective effects of TCCE. In addition, the disruption of mitochondrial membrane potential (14.8%), intramitochondrial Ca2+ overload (2.1-fold) and suppression of mitochondrial Ca2+-ATPase activity (42.0%) in the liver of CCl4-insulted mice were effectively prevented by pretreatment with TCCE. It can be concluded that TCCE have protective activities against liver mitochondrial damage induced by CCl4, which suggests a new mechanism of the hepatoprotective effects of TCCE.Entities:
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Year: 2005 PMID： 16169207 DOI： 10.1016/j.jnutbio.2005.06.008
Source DB: PubMed Journal: J Nutr Biochem ISSN： 0955-2863 Impact factor: 6.048