Literature DB >> 16168660

99mTc-labeled 1-thio-beta-D-glucose as a new tumor-seeking agent: synthesis and tumor cell uptake assay.

Seung Jun Oh1, Jin-Sook Ryu, Eun-Jin Yoon, Mun Sun Bae, Sun Joo Choi, Kyung Bae Park, Dae Hyuk Moon.   

Abstract

99mTc-labeled 1-thio-beta-D-glucose (99mTc-1-TG) was synthesized under different ligand concentrations. 1-Thio-beta-D-glucose (1-TG) showed different chemical properties and higher stability at acid pH as compared to neutral and basic pH. Under different ligand concentrations, 99mTc-1-TG was obtained with high labeling efficiency of >97%, but the HPLC chromatogram varied with the ligand concentration. The results of a tumor cell uptake assay also depended on the ligand concentration. With the lowest ligand concentration tested (0.5 mg/ml of 1-TG), we obtained the highest uptake. With different glucose and insulin concentrations, 99mTc-1-TG uptake was not significantly different from that of [18F]FDG.

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Year:  2005        PMID： 16168660     DOI： 10.1016/j.apradiso.2005.07.022

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  4 in total

1.  Phase I Clinical Trial Using [99mTc]Tc-1-thio-D-glucose for Diagnosis of Lymphoma Patients.

Authors:  Vladimir Chernov; Ekaterina Dudnikova; Roman Zelchan; Anna Medvedeva; Anstasiya Rybina; Olga Bragina; Viktor Goldberg; Albina Muravleva; Jens Sörensen; Vladimir Tolmachev
Journal:  Pharmaceutics       Date:  2022-06-15       Impact factor: 6.525

2.  Tumor cell uptake of 99mTc-labeled 1-thio-β-D-glucose and 5-thio-D-glucose in comparison with 2-deoxy-2-[18F]fluoro-D-glucose in vitro: kinetics, dependencies, blockage and cell compartment of accumulation.

Authors:  M Seidensticker; G Ulrich; F L Muehlberg; A Pethe; O S Grosser; I G Steffen; M Stiebler; J Goldschmidt; K H Smalla; R Seidensticker; J Ricke; H Amthauer; K Mohnike
Journal:  Mol Imaging Biol       Date:  2014-04       Impact factor: 3.488

3.  Synthesis, Radiolabeling and Biological Evaluation of (99m)Tc-labeled Deoxyglucose Derivatives for Molecular Imaging.

Authors:  Masoud Sadeghzadeh; Ghorbanali Charkhlooiea; Fariba Johari Daha
Journal:  Iran J Pharm Res       Date:  2013       Impact factor: 1.696

Review 4.  Nuclear Imaging of Glucose Metabolism: Beyond 18F-FDG.

Authors:  Han Feng; Xiaobo Wang; Jian Chen; Jing Cui; Tang Gao; Yongju Gao; Wenbin Zeng
Journal:  Contrast Media Mol Imaging       Date:  2019-03-26       Impact factor: 3.161
  4 in total

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