| Literature DB >> 16168649 |
Caroline J Goodacre1, Steven M Bromidge, David Clapham, Frank D King, Peter J Lovell, Mike Allen, Lorraine P Campbell, Vicky Holland, Graham J Riley, Kathryn R Starr, Brenda K Trail, Martyn D Wood.
Abstract
Bisaryl cyclic ureas have been identified as high affinity 5-HT2C receptor antagonists with selectivity over 5-HT2A and 5-HT2B. Compounds such as 8 and 22 have shown oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function in rodents.Entities:
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Year: 2005 PMID： 16168649 DOI： 10.1016/j.bmcl.2005.08.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823