Literature DB >> 16168529

Evidence for adjuvanticity of anthrax edema toxin.

Anne Quesnel-Hellmann1, Aurélie Cleret, Dominique R Vidal, Jean-Nicolas Tournier.   

Abstract

Bacillus anthracis edema factor (EF) is an adenylate cyclase that increases intracellular cAMP concentrations. Since EF is present as a contaminant in the licensed protective antigen(PA)-based vaccines, we investigated its effect on anti-PA humoral immune response in BALB/c mice. We observed a significant increase of anti-PA IgG response in mice immunised with PA in association with EF as compared to PA alone. These results clearly show an adjuvant effect of EF, which is consistent with the data concerning the cellular effects of EF on antigen-presenting cells.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16168529     DOI： 10.1016/j.vaccine.2005.08.065

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  6 in total

1.  A dual purpose universal influenza vaccine candidate confers protective immunity against anthrax.

Authors:  Maria T Arévalo; Junwei Li; Diana Diaz-Arévalo; Yanping Chen; Ashley Navarro; Lihong Wu; Yongyong Yan; Mingtao Zeng
Journal:  Immunology       Date:  2016-12-05       Impact factor: 7.397

2.  Group 3 innate lymphocytes (ILC3s) upregulate IL-22 in response to elevated intracellular cAMP levels.

Authors:  Prakash Sah; Jonathan T Derouen; Justine L Alexander; Lauren A Zenewicz
Journal:  Cytokine       Date:  2022-03-17       Impact factor: 3.926

3.  Neutralizing activity of vaccine-induced antibodies to two Bacillus anthracis toxin components, lethal factor and edema factor.

Authors:  Sarah C Taft; Alison A Weiss
Journal:  Clin Vaccine Immunol       Date:  2007-11-21

4.  Both lethal and edema toxins of Bacillus anthracis disrupt the human dendritic cell chemokine network.

Authors:  Aurélie Cleret-Buhot; Jacques Mathieu; Jean-Nicolas Tournier; Anne Quesnel-Hellmann
Journal:  PLoS One       Date:  2012-08-24       Impact factor: 3.240

Review 5.  T cell targeting by anthrax toxins: two faces of the same coin.

Authors:  Silvia Rossi Paccani; Cosima T Baldari
Journal:  Toxins (Basel)       Date:  2011-06-20       Impact factor: 4.546

6.  The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling.

Authors:  Silvia Rossi Paccani; Marisa Benagiano; Nagaja Capitani; Irene Zornetta; Daniel Ladant; Cesare Montecucco; Mario M D'Elios; Cosima T Baldari
Journal:  PLoS Pathog       Date:  2009-03-06       Impact factor: 6.823
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.